1j9j

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[[Image:1j9j.jpg|left|200px]]
 
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==CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA==
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The line below this paragraph, containing "STRUCTURE_1j9j", creates the "Structure Box" on the page.
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<StructureSection load='1j9j' size='340' side='right'caption='[[1j9j]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1j9j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J9J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1j9j| PDB=1j9j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j9j OCA], [https://pdbe.org/1j9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j9j RCSB], [https://www.ebi.ac.uk/pdbsum/1j9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j9j ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA'''
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== Function ==
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[https://www.uniprot.org/uniprot/SURE_THEMA SURE_THEMA] Nucleotidase that preferentially dephosphorylates 5'-GMP and 5'-AMP.[HAMAP-Rule:MF_00060]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/1j9j_consurf.spt"</scriptWhenChecked>
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1J9J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J9J OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11524683 11524683]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j9j ConSurf].
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[[Category: Single protein]]
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<div style="clear:both"></div>
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[[Category: Thermotoga maritima]]
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__TOC__
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[[Category: Kwak, J E.]]
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</StructureSection>
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[[Category: Lee, J Y.]]
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[[Category: Large Structures]]
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[[Category: Moon, J.]]
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[[Category: Suh, S W.]]
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[[Category: Sure protein]]
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[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:57:00 2008''
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[[Category: Kwak JE]]
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[[Category: Lee JY]]
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[[Category: Moon J]]
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[[Category: Suh SW]]

Current revision

CRYSTAL STRUCTURE ANALYSIS OF SURE PROTEIN FROM T.MARITIMA

PDB ID 1j9j

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