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1jas

From Proteopedia

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[[Image:1jas.gif|left|200px]]
 
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<!--
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==HsUbc2b==
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The line below this paragraph, containing "STRUCTURE_1jas", creates the "Structure Box" on the page.
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<StructureSection load='1jas' size='340' side='right'caption='[[1jas]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jas]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JAS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jas OCA], [https://pdbe.org/1jas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jas RCSB], [https://www.ebi.ac.uk/pdbsum/1jas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jas ProSAT]</span></td></tr>
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{{STRUCTURE_1jas| PDB=1jas | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBE2B_HUMAN UBE2B_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.<ref>PMID:1717990</ref> <ref>PMID:16337599</ref> <ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:20061386</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/1jas_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jas ConSurf].
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<div style="clear:both"></div>
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'''HsUbc2b'''
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==See Also==
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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== References ==
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==About this Structure==
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<references/>
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1JAS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAS OCA].
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__TOC__
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</StructureSection>
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==Reference==
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The NMR structure of the class I human ubiquitin-conjugating enzyme 2b., Miura T, Klaus W, Ross A, Guntert P, Senn H, J Biomol NMR. 2002 Jan;22(1):89-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11885984 11885984]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Guentert P]]
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[[Category: Guentert, P.]]
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[[Category: Klaus W]]
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[[Category: Klaus, W.]]
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[[Category: Miura T]]
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[[Category: Miura, T.]]
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[[Category: Ross A]]
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[[Category: Ross, A.]]
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[[Category: Senn H]]
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[[Category: Senn, H.]]
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[[Category: Nmr structure]]
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[[Category: Ubiquitin conjugating enzyme]]
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[[Category: Ubiquitin conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:59:31 2008''
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Current revision

HsUbc2b

PDB ID 1jas

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