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8bx1
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8bx1 is ON HOLD Authors: Chojnowski, G., Wilmanns, M., Round, E. Description: Oct4/Sox2 protein:DNA complex Category: Unreleased Structures [[C...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Oct4/Sox2 protein:DNA complex== | |
| - | + | <StructureSection load='8bx1' size='340' side='right'caption='[[8bx1]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bx1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BX1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bx1 OCA], [https://pdbe.org/8bx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bx1 RCSB], [https://www.ebi.ac.uk/pdbsum/8bx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bx1 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Round | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PO5F1_MOUSE PO5F1_MOUSE] Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.<ref>PMID:17496161</ref> <ref>PMID:17525163</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Chojnowski G]] | ||
| + | [[Category: Round E]] | ||
| + | [[Category: Wilmanns M]] | ||
Current revision
Oct4/Sox2 protein:DNA complex
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