1jbb

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[[Image:1jbb.jpg|left|200px]]
 
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==Ubiquitin Conjugating Enzyme, Ubc13==
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The line below this paragraph, containing "STRUCTURE_1jbb", creates the "Structure Box" on the page.
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<StructureSection load='1jbb' size='340' side='right'caption='[[1jbb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jbb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JBB FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jbb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbb OCA], [https://pdbe.org/1jbb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jbb RCSB], [https://www.ebi.ac.uk/pdbsum/1jbb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jbb ProSAT]</span></td></tr>
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{{STRUCTURE_1jbb| PDB=1jbb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBC13_YEAST UBC13_YEAST] Has a role in the DNA error-free postreplication repair (PRR) pathway. The UBC13/MMS2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/1jbb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jbb ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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While the signaling properties of ubiquitin depend on the topology of polyubiquitin chains, little is known concerning the molecular basis of specificity in chain assembly and recognition. UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and I kappa B alpha kinase activation. The crystal structure of the Mms2/Ubc13 heterodimer shows the active site of Ubc13 at the intersection of two channels that are potential binding sites for the two substrate ubiquitins. Mutations that destabilize the heterodimer interface confer a marked UV sensitivity, providing direct evidence that the intact heterodimer is necessary for DNA repair. Selective mutations in the channels suggest a molecular model for specificity in the assembly of Lys63-linked polyubiquitin signals.
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'''Ubiquitin Conjugating Enzyme, Ubc13'''
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Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.,VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C Cell. 2001 Jun 15;105(6):711-20. PMID:11440714<ref>PMID:11440714</ref>
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==Overview==
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While the signaling properties of ubiquitin depend on the topology of polyubiquitin chains, little is known concerning the molecular basis of specificity in chain assembly and recognition. UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and I kappa B alpha kinase activation. The crystal structure of the Mms2/Ubc13 heterodimer shows the active site of Ubc13 at the intersection of two channels that are potential binding sites for the two substrate ubiquitins. Mutations that destabilize the heterodimer interface confer a marked UV sensitivity, providing direct evidence that the intact heterodimer is necessary for DNA repair. Selective mutations in the channels suggest a molecular model for specificity in the assembly of Lys63-linked polyubiquitin signals.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1JBB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JBB OCA].
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</div>
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<div class="pdbe-citations 1jbb" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer., VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C, Cell. 2001 Jun 15;105(6):711-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11440714 11440714]
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Hofmann RM]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Pickart CM]]
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[[Category: Hofmann, R M.]]
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[[Category: Tsui C]]
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[[Category: Pickart, C M.]]
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[[Category: VanDemark AP]]
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[[Category: Tsui, C.]]
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[[Category: Wolberger C]]
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[[Category: VanDemark, A P.]]
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[[Category: Wolberger, C.]]
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[[Category: E2]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin-conjugating enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:00:39 2008''
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Current revision

Ubiquitin Conjugating Enzyme, Ubc13

PDB ID 1jbb

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