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8hnl
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8hnl is ON HOLD Authors: Jiao, H.Z., Hu, H.L. Description: CXCR3-DNGi complex activated by PS372424 Category: Unreleased Structures [[Category:...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==CXCR3-DNGi complex activated by PS372424== | |
| + | <StructureSection load='8hnl' size='340' side='right'caption='[[8hnl]], [[Resolution|resolution]] 2.98Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8hnl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Oplophorus_gracilirostris Oplophorus gracilirostris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HNL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.98Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4AI:(3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide'>4AI</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hnl OCA], [https://pdbe.org/8hnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hnl RCSB], [https://www.ebi.ac.uk/pdbsum/8hnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hnl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Transducin 3D structures|Transducin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Hu | + | </StructureSection> |
| + | [[Category: Escherichia coli]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oplophorus gracilirostris]] | ||
| + | [[Category: Hu HL]] | ||
| + | [[Category: Jiao HZ]] | ||
Current revision
CXCR3-DNGi complex activated by PS372424
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