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Cytochrome P450 3D structures

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Line 274: Line 274:
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br />
**[[5l91]], [[5l92]] - BmP450 CYP109E1 + corticosterone<br />
**[[5l94]] - BmP450 CYP109E1 + testosterone<br />
**[[5l94]] - BmP450 CYP109E1 + testosterone<br />
-
**[[7f3h]] - P450 heme domain – Deinococcus aerius<br />
+
**[[7f3h]] - P450 heme domain – ''Deinococcus aerius''<br />
-
**[[7f3w]] - P450 heme domain – Deinococcus apachensis<br />
+
**[[7f3w]] - P450 heme domain – ''Deinococcus apachensis''<br />
*Eukaryote P450 Cyp51 or lanosterol 14-alpha demethylase
*Eukaryote P450 Cyp51 or lanosterol 14-alpha demethylase
Line 288: Line 288:
**[[4zdy]], [[4zdz]], [[4ze0]], [[4ze1]], [[4ze2]], [[4ze3]], [[5ese]], [[5esf]], [[5esg]], [[5esh]], [[5esj]], [[5esk]], [[5esl]], [[5esm]], [[7ry8]], [[7ry9]], [[7rya]], [[7ryb]] – yCyp51 (mutant) + drug<br />
**[[4zdy]], [[4zdz]], [[4ze0]], [[4ze1]], [[4ze2]], [[4ze3]], [[5ese]], [[5esf]], [[5esg]], [[5esh]], [[5esj]], [[5esk]], [[5esl]], [[5esm]], [[7ry8]], [[7ry9]], [[7rya]], [[7ryb]] – yCyp51 (mutant) + drug<br />
**[[4lxj]] – yCyp51 + lanosterol<br />
**[[4lxj]] – yCyp51 + lanosterol<br />
-
**[[5v5z]] – CaP450 CYP51 – Candida albicans<br />
+
**[[5v5z]] – CaP450 CYP51 – ''Candida albicans''<br />
**[[5tz1]] – CaP450 CYP51 + drug <br />
**[[5tz1]] – CaP450 CYP51 + drug <br />
**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
**[[5fsa]] – CaP450 CYP51 (mutant) + drug <br />
 +
*Bacterial P450 Cyp51 or lanosterol 14-alpha demethylase
*Bacterial P450 Cyp51 or lanosterol 14-alpha demethylase
-
**[[6mi0], [[7jj1]]] – McP450 CYP51 – Methylcoccus capsulatus<br />
+
**[[6mi0]], [[7jj1]]– McP450 CYP51 – ''Methylcoccus capsulatus''<br />
-
**[[7tef]] – MmP450 CYP51B1 – Mycobacterium marinum<br />
+
**[[7tef]] – MmP450 CYP51B1 – ''Mycobacterium marinum''<br />
-
**[[3g1q]] – TbP450 CYP51 – Trypanosoma brucei<br />
+
**[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br />
-
**[[5jlc]] – P450 CYP51 – Candida glabrata<br />
+
**[[5jlc]] – P450 CYP51 – ''Candida glabrata<''br />
-
**[[4bmm]], [[4by0]], [[4c0c]], [[4c27]], [[4c28]], [[4coh]], [[4uqh]], [[4uvr]] – P450 CYP51 + inhibitor – Trypanosoma cruzi<br />
+
**[[4bmm]], [[4by0]], [[4c0c]], [[4c27]], [[4c28]], [[4coh]], [[4uqh]], [[4uvr]] – P450 CYP51 + inhibitor – ''Trypanosoma cruzi''<br />
**[[6fmo]] – P450 CYP51 (mutant) + obtosifoliol <br />
**[[6fmo]] – P450 CYP51 (mutant) + obtosifoliol <br />
**[[6mcw]] – McP450 CYP51 + detergent <br />
**[[6mcw]] – McP450 CYP51 + detergent <br />
Line 305: Line 306:
**[[3gw9]], [[4bjk]], [[4g3j]], [[4g7g]] – TbP450 CYP51 + inhibitor<br />
**[[3gw9]], [[4bjk]], [[4g3j]], [[4g7g]] – TbP450 CYP51 + inhibitor<br />
**[[3p99]] – TbP450 CYP51 + lanosterol derivative<br />
**[[3p99]] – TbP450 CYP51 + lanosterol derivative<br />
-
**[[6ay4]], [[6ayb]], [[6ayc]] – NfP450 CYP51 + drug – Naegleria fowleri<br />
+
**[[6ay4]], [[6ayb]], [[6ayc]] – NfP450 CYP51 + drug – ''Naegleria fowleri''<br />
-
**[[3l4d]] – P450 CYP51 + drug – Leishmania infantum<br />
+
**[[3l4d]] – P450 CYP51 + drug – ''Leishmania infantum''<br />
* Other CYPs
* Other CYPs
Line 319: Line 320:
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
**[[1wiy]] – TtP450 – ''Thermus thermophilus''<br />
**[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br />
**[[4e2p]], [[5xw2]] - P450 – ''Streptococcus himastatinicus''<br />
-
**[[6g5q]], [[6g5o]] - P450 – Zobellia galactanivorans<br />
+
**[[6g5q]], [[6g5o]] - P450 – ''Zobellia galactanivorans''<br />
-
**[[5ysm]] – AmP450 – Amycolatopsis mediterranei<br />
+
**[[5ysm]] – AmP450 – ''Amycolatopsis mediterranei''<br />
-
**[[6f0c]], [[6f0b]] - P450 TXTC – Streptomyces acidiscabies<br />
+
**[[6f0c]], [[6f0b]] - P450 TXTC – ''Streptomyces acidiscabies''<br />
-
**[[5gwe]], [[7ccf]] – CgP450 CreJ – Corynebacterium glutamicum<br />
+
**[[5gwe]], [[7ccf]] – CgP450 CreJ – ''Corynebacterium glutamicum''<br />
-
**[[5y1i]] - P450 GFSF – Streptomyces graminofaciens<br />
+
**[[5y1i]] - P450 GFSF – ''Streptomyces graminofaciens''<br />
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br />
**[[1cpt]] – PsP450 TERP - ''Pseudomonas sp.''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
**[[4l0e]], [[4l0f]] - StP450 SKY32– ''Streptomyces''<br />
Line 330: Line 331:
**[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br />
**[[3a4z]], [[5gnm]], [[5gnl]] - PaP450 VDH (mutant)<br />
**[[3qi8]] – P450 – synthetic<br />
**[[3qi8]] – P450 – synthetic<br />
-
**[[3g1q]] – TbP450 CYP51 – Trypanosoma brucei<br />
+
**[[3g1q]] – TbP450 CYP51 – ''Trypanosoma brucei''<br />
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
**[[3dam]], [[3dan]], [[3dbm]] – P45074A2 – ''Parthenium argentatum''<br />
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
**[[2rcm]], [[3cli]] - AtP45074A - ''Arabidopsis thaliana''<br />
Line 342: Line 343:
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
**[[3e5j]], [[3e5l]] - SaP450 CYP105P1 (mutant)<br />
**[[2z3u]] - SgP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
**[[2z3u]] - SgP450 CYP105A1 (mutant) – ''Streptomyces griseolus''<br />
-
**[[5xnt]] - P450 CYP106A2 – Bacillus butanolivorans<br />
+
**[[5xnt]] - P450 CYP106A2 – ''Bacillus butanolivorans''<br />
-
**[[6l39]] - SrP450 CYP107G1 – Streptomyces rapamycinicus<br />
+
**[[6l39]] - SrP450 CYP107G1 – ''Streptomyces rapamycinicus''<br />
**[[4wpz]] - SaP450 CYP107W1 <br />
**[[4wpz]] - SaP450 CYP107W1 <br />
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
**[[2whw]], [[2wi9]], [[2vz7]] – SvP450107L1 (mutant) – ''Streptomyces venezuelae''<br />
Line 351: Line 352:
**[[4rm4]] - BsP450 CYP109B1<br />
**[[4rm4]] - BsP450 CYP109B1<br />
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
**[[2jjn]], [[2jjo]] - SeP450 CYP113A1 (mutant) - ''Saccharopolyspora erythraea''<br />
-
**[[6ro8]] - P450 CYP116B5 – Acinetobacter radioresistens<br />
+
**[[6ro8]] - P450 CYP116B5 – ''Acinetobacter radioresistens''<br />
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[1io8]], [[5bv5]] – SsP450 CYP119 (mutant) – ''Sulfolobus solfataricus''<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
**[[1io9]], [[1io7]], [[1f4u]] - SsP450 CYP119<br />
Line 362: Line 363:
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br />
**[[6hqg]] - P450 CYP153 – ''Phenylobacterium zucineum''<br />
**[[6hqd]] – PsP450 CYP153 <br />
**[[6hqd]] – PsP450 CYP153 <br />
-
**[[7ant]] – PoP450 CYP153 - Polaromonas<br />
+
**[[7ant]] – PoP450 CYP153 - ''Polaromonas''<br />
**[[1gwi]] - ScP450 CYP154C1<br />
**[[1gwi]] - ScP450 CYP154C1<br />
**[[6a7i]] - SvP450 CYP154C4 – Streptomyces violaceruber<br />
**[[6a7i]] - SvP450 CYP154C4 – Streptomyces violaceruber<br />
Line 376: Line 377:
**[[5hiw]] - ScP450 CYP260B1 <br />
**[[5hiw]] - ScP450 CYP260B1 <br />
**[[6gk5]] - ScP450 CYP267B1 <br />
**[[6gk5]] - ScP450 CYP267B1 <br />
-
**[[6g71]] - P450 CYP1232A24 - Arthrobacter<br />
+
**[[6g71]] - P450 CYP1232A24 - ''Arthrobacter<''br />
-
**[[6m4q]] - SspP450 – Streptomyces spectabilis<br />
+
**[[6m4q]] - SspP450 – ''Streptomyces spectabilis''<br />
-
**[[6j82]] - SbP450 TleB – Streptomyces blastmyceticus<br />
+
**[[6j82]] - SbP450 TleB – ''Streptomyces blastmyceticus''<br />
-
**[[7ayx]] - P450 AryC – Streptomyces filamentosus<br />
+
**[[7ayx]] - P450 AryC – ''Streptomyces filamentosus''<br />
-
**[[7oq6]] - P450 Sas16 – Streptomyces calvus<br />
+
**[[7oq6]] - P450 Sas16 –'' Streptomyces calvus''<br />
**[[6kbh]] – ReP450 – ''Rhodococcus erythropolis''<br />
**[[6kbh]] – ReP450 – ''Rhodococcus erythropolis''<br />
**[[7v40]] – RcP450 – ''Rhodococcus coprophilus''<br />
**[[7v40]] – RcP450 – ''Rhodococcus coprophilus''<br />
-
**[[6zhz]] - SanP450 – Streptomyces antibioticus<br />
+
**[[6zhz]] - SanP450 – ''Streptomyces antibioticus''<br />
-
**[[7qan]] - P450 – Micromonospora maris<br />
+
**[[7qan]] - P450 – ''Micromonospora maris"<br />
*Other CYPs complexes
*Other CYPs complexes
Line 407: Line 408:
**[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br />
**[[3dsj]] - AtP450 CYP74A (mutant)+13(S)-HOD<br />
**[[2rcl]] - AtP450 CYP74A+vernolic acid<br />
**[[2rcl]] - AtP450 CYP74A+vernolic acid<br />
-
**[[7p6l]] - P450 CYP505A30 + dodecanoic acid – Mycelyophthora thermophila<br />
+
**[[7p6l]] - P450 CYP505A30 + dodecanoic acid – ''Mycelyophthora thermophila"<br />
-
**[[3dsk]] - AtP450 CYP74A (mutant)+ vernolic acid<br />
+
**[[6a15]] - AtP450 CYP90B1 (mutant) + cholesterol<br />
**[[6a15]] - AtP450 CYP90B1 (mutant) + cholesterol<br />
**[[6a16]] - AtP450 CYP90B1 (mutant) + uniconazole<br />
**[[6a16]] - AtP450 CYP90B1 (mutant) + uniconazole<br />
Line 415: Line 415:
**[[6j94]] - AtP450 CYP97A3 + retinal<br />
**[[6j94]] - AtP450 CYP97A3 + retinal<br />
**[[6l8j]] - AtP450 CYP97A3 (mutant) + retinal<br />
**[[6l8j]] - AtP450 CYP97A3 (mutant) + retinal<br />
- 
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
**[[3cv9]], [[2zbz]] - SgP450 CYP105A1 (mutant)+vitamin D3<br />
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
**[[2zbx]] - SgP450 CYP105A1+imidazole<br />
Line 423: Line 422:
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
**[[4oqr]] - AoP450 CYP105AS1 (mutant) + compactin<br />
**[[7q9e]] - PmP450 CYP106A1 – Priestia megaterium<br />
**[[7q9e]] - PmP450 CYP106A1 – Priestia megaterium<br />
-
**[[7cvr]], [[7cx6], [[7czi]] - PmP450 CYP106A1 + inhibitor<br />
+
**[[7cvr]], [[7cx6]], [[7czi]] - PmP450 CYP106A1 + inhibitor<br />
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br />
**[[1jin]], [[1jip]] - SeP450 CYP107A1+ ketoconazole <br />
**[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br />
**[[1jio]], [[1oxa]] - SeP450 CYP107A1+6DEB<br />
Line 434: Line 433:
**[[2c7x]] - SvP450 CYP107L1+narbomycin<br />
**[[2c7x]] - SvP450 CYP107L1+narbomycin<br />
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br />
**[[2cd8]], [[2ca0]], [[2c6h]] – SvP450 CYP107L1+YC-17<br />
-
 
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
**[[4tt5]], [[4tuv]], [[4wpd]], [[4wqj]] - P450 CYP119+ imidazole derivative – ''Sulfolobus acidocaldarius''<br />
**[[7smz]] – MmP450 CYP142A3 + cholestenone<br />
**[[7smz]] – MmP450 CYP142A3 + cholestenone<br />
-
**[[5yhj]] - P450 CYP152N1 + myristic acid - Exiguobacterium<br />
+
**[[5yhj]] - P450 CYP152N1 + myristic acid - ''Exiguobacterium''<br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
**[[5fyg]] - MhP450 CYP153A + dodecanoic acid<br />
**[[7ao7]] – PoP450 CYP153 + octanol <br />
**[[7ao7]] – PoP450 CYP153 + octanol <br />
-
**[[6to2]] - NfP450 CYP154C4 + androstan derivative – Nocardia farcinica <br />
+
**[[6to2]] - NfP450 CYP154C4 + androstan derivative – ''Nocardia farcinica'' <br />
**[[4j6b]], [[4jbc]], [[4jbd]], [[4jbt]] - NfP450 CYP154C5 + hormone<br />
**[[4j6b]], [[4jbc]], [[4jbd]], [[4jbt]] - NfP450 CYP154C5 + hormone<br />
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br />
**[[6a7j]] - SvP450 CYP154C4 + testosterone <br />
Line 448: Line 446:
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egn]] – RpP450 CYP199A4 + veratric acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
**[[4egp]] – RpP450 CYP199A4 + naphthoic acid<br />
-
**[[46unn]] – RpP450 CYP199A4 + cinnamic acid derivative<br />
+
**[[6unn]] – RpP450 CYP199A4 + cinnamic acid derivative<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
**[[4ego]] – RpP450 CYP199A4 + indole derivative<br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />
**[[3a1l]] – StrP450 CYP245A1+dichlorochrompyrrolic acid <br />

Current revision

3D Structures of Cytochrome P450

Updated on 15-December-2022

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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