8b4e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==ToxR bacterial transcriptional regulator bound to 25 bp toxT promoter DNA== | |
| + | <StructureSection load='8b4e' size='340' side='right'caption='[[8b4e]], [[Resolution|resolution]] 3.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8b4e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B4E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b4e OCA], [https://pdbe.org/8b4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b4e RCSB], [https://www.ebi.ac.uk/pdbsum/8b4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b4e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TOXR_VIBCH TOXR_VIBCH] This transcription activator controls cholera toxin, pilus colonization factor and outer membrane protein expression in V.cholerae. It binds to the 5'-TTTTGAT-3' tandemly repeated DNA sequence in the cholera toxin promoter region. ToxS interacts with the C-terminal periplasmic domain of ToxR, stimulating its activity. It activates transcription at the promoters for tcpI and tcpA and this is presumably via ToxT. | ||
| - | + | ==See Also== | |
| - | + | *[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vibrio cholerae]] | ||
| + | [[Category: Canals A]] | ||
| + | [[Category: Coll M]] | ||
| + | [[Category: El Yaman N]] | ||
| + | [[Category: Fabrega-Ferrer M]] | ||
| + | [[Category: Krukonis ES]] | ||
| + | [[Category: Muriel M]] | ||
| + | [[Category: Perez-Luque R]] | ||
| + | [[Category: Pieretti S]] | ||
Current revision
ToxR bacterial transcriptional regulator bound to 25 bp toxT promoter DNA
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