8bo5

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'''Unreleased structure'''
 
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The entry 8bo5 is ON HOLD until Paper Publication
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==COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR 3==
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<StructureSection load='8bo5' size='340' side='right'caption='[[8bo5]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Schaefer, M., Roehrig, S., Ackerstaff, J., Nunez, E.J., Gericke, K.M., Meier, K., Tersteegen, A., Stampfuss, J., Ellerbrock, P., Meibom, D., Lang, D., Heitmeier, S., Hillisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8bo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BO5 FirstGlance]. <br>
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Description: COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR 3
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=QVO:2-[4-(3-chlorophenyl)-2,5-bis(oxidanylidene)pyrrolo[3,4-b]pyridin-1-yl]-~{N}-[4-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]ethanamide'>QVO</scene></td></tr>
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[[Category: Ellerbrock, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bo5 OCA], [https://pdbe.org/8bo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bo5 RCSB], [https://www.ebi.ac.uk/pdbsum/8bo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bo5 ProSAT]</span></td></tr>
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[[Category: Hillisch, A]]
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</table>
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[[Category: Gericke, K.M]]
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== Disease ==
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[[Category: Ackerstaff, J]]
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[https://omim.org/entry/612416 612416]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
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[[Category: Nunez, E.J]]
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== Function ==
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[[Category: Heitmeier, S]]
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[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
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[[Category: Meier, K]]
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== References ==
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[[Category: Lang, D]]
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<references/>
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[[Category: Stampfuss, J]]
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__TOC__
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[[Category: Schaefer, M]]
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</StructureSection>
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[[Category: Roehrig, S]]
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[[Category: Homo sapiens]]
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[[Category: Tersteegen, A]]
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[[Category: Large Structures]]
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[[Category: Meibom, D]]
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[[Category: Ackerstaff J]]
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[[Category: Ellerbrock P]]
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[[Category: Gericke KM]]
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[[Category: Heitmeier S]]
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[[Category: Hillisch A]]
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[[Category: Lang D]]
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[[Category: Meibom D]]
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[[Category: Meier K]]
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[[Category: Nunez EJ]]
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[[Category: Roehrig S]]
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[[Category: Schaefer M]]
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[[Category: Stampfuss J]]
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[[Category: Tersteegen A]]

Current revision

COAGULATION FACTOR XI PROTEASE DOMAIN IN COMPLEX WITH ACTIVE SITE INHIBITOR 3

PDB ID 8bo5

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