8bzt
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8bzt is ON HOLD Authors: Visser, E.J., Ottmann, C. Description: FC-NAg stabilizer of 14-3-3 and ERalpha Category: Unreleased Structures [[Categ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==FC-NAg stabilizer of 14-3-3 and ERalpha== | |
| - | + | <StructureSection load='8bzt' size='340' side='right'caption='[[8bzt]], [[Resolution|resolution]] 1.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BZT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SKR:~{N}-[(2~{S})-2-[(1~{E},3~{R},4~{S},8~{R},9~{R},10~{R},11~{S},14~{S})-14-(methoxymethyl)-3,10-dimethyl-4,8,9-tris(oxidanyl)-6-tricyclo[9.3.0.0^{3,7}]tetradeca-1,6-dienyl]propyl]ethanamide'>SKR</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> |
| - | [[Category: Ottmann | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bzt OCA], [https://pdbe.org/8bzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bzt RCSB], [https://www.ebi.ac.uk/pdbsum/8bzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bzt ProSAT]</span></td></tr> |
| - | [[Category: Visser | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ottmann C]] | ||
| + | [[Category: Visser EJ]] | ||
Current revision
FC-NAg stabilizer of 14-3-3 and ERalpha
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