1jgk

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[[Image:1jgk.gif|left|200px]]
 
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==SOLUTION STRUCTURE OF CANDOXIN==
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The line below this paragraph, containing "STRUCTURE_1jgk", creates the "Structure Box" on the page.
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<StructureSection load='1jgk' size='340' side='right'caption='[[1jgk]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_candidus Bungarus candidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 19 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgk OCA], [https://pdbe.org/1jgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgk RCSB], [https://www.ebi.ac.uk/pdbsum/1jgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgk ProSAT]</span></td></tr>
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{{STRUCTURE_1jgk| PDB=1jgk | SCENE= }}
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</table>
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== Function ==
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'''SOLUTION STRUCTURE OF CANDOXIN'''
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[https://www.uniprot.org/uniprot/3NO4_BUNCA 3NO4_BUNCA] Binds and inhibits muscular and neuronal nicotinic acetylcholine receptors (nAChR). Is a reversible antagonist of muscle nAChR (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) (IC(50)=10 nM) and a potent and poorly reversible antagonist of the neuronal alpha-7/CHRNA7 nAChR (IC(50)=50 nM). May exhibit differential affinities for the two binding sites on the muscle nAChR.<ref>PMID:11884390</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1JGK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bungarus_candidus Bungarus candidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGK OCA].
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<jmolCheckbox>
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[[Category: Bungarus candidus]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgk_consurf.spt"</scriptWhenChecked>
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[[Category: Single protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: Chary, K V.R.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Govil, G.]]
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</jmolCheckbox>
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[[Category: Kini, M R.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgk ConSurf].
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[[Category: Venkitakrishnan, R P.]]
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<div style="clear:both"></div>
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[[Category: Beta sheet]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bungarus candidus]]
[[Category: Bungarus candidus]]
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[[Category: Snake venom protein]]
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[[Category: Large Structures]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:11:47 2008''
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[[Category: Chary KVR]]
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[[Category: Govil G]]
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[[Category: Kini MR]]
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[[Category: Venkitakrishnan RP]]

Current revision

SOLUTION STRUCTURE OF CANDOXIN

PDB ID 1jgk

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