7frx

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m (Protected "7frx" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 7frx is ON HOLD
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==Structure of liver pyruvate kinase in complex with allosteric modulator 5==
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<StructureSection load='7frx' size='340' side='right'caption='[[7frx]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7frx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FRX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.847&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=O88:N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-3,4-dihydroxybenzene-1-sulfonamide'>O88</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7frx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7frx OCA], [https://pdbe.org/7frx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7frx RCSB], [https://www.ebi.ac.uk/pdbsum/7frx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7frx ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KPYR_HUMAN KPYR_HUMAN] Defects in PKLR are the cause of pyruvate kinase hyperactivity (PKHYP) [MIM:[https://omim.org/entry/102900 102900]; also known as high red cell ATP syndrome. This autosomal dominant phenotype is characterized by increase of red blood cell ATP.<ref>PMID:9090535</ref> Defects in PKLR are the cause of pyruvate kinase deficiency of red cells (PKRD) [MIM:[https://omim.org/entry/266200 266200]. A frequent cause of hereditary non-spherocytic hemolytic anemia. Clinically, pyruvate kinase-deficient patients suffer from a highly variable degree of chronic hemolysis, ranging from severe neonatal jaundice and fatal anemia at birth, severe transfusion-dependent chronic hemolysis, moderate hemolysis with exacerbation during infection, to a fully compensated hemolysis without apparent anemia.
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== Function ==
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[https://www.uniprot.org/uniprot/KPYR_HUMAN KPYR_HUMAN] Plays a key role in glycolysis (By similarity).
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Authors: Lulla, A., Nilsson, O., Brear, P., Nain-Perez, A., Grotli, M., Hyvonen, M.
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==See Also==
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*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]
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Description: Structure of liver pyruvate kinase in complex with allosteric modulator 5
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Brear, P]]
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__TOC__
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[[Category: Hyvonen, M]]
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</StructureSection>
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[[Category: Nilsson, O]]
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[[Category: Homo sapiens]]
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[[Category: Lulla, A]]
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[[Category: Large Structures]]
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[[Category: Grotli, M]]
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[[Category: Brear P]]
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[[Category: Nain-Perez, A]]
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[[Category: Grotli M]]
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[[Category: Hyvonen M]]
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[[Category: Lulla A]]
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[[Category: Nain-Perez A]]
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[[Category: Nilsson O]]

Current revision

Structure of liver pyruvate kinase in complex with allosteric modulator 5

PDB ID 7frx

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