1jgs

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[[Image:1jgs.jpg|left|200px]]
 
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==Multiple Antibiotic Resistance Repressor, MarR==
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The line below this paragraph, containing "STRUCTURE_1jgs", creates the "Structure Box" on the page.
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<StructureSection load='1jgs' size='340' side='right'caption='[[1jgs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
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{{STRUCTURE_1jgs| PDB=1jgs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgs OCA], [https://pdbe.org/1jgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgs RCSB], [https://www.ebi.ac.uk/pdbsum/1jgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgs ProSAT]</span></td></tr>
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</table>
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'''Multiple Antibiotic Resistance Repressor, MarR'''
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== Function ==
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[https://www.uniprot.org/uniprot/MARR_ECOLI MARR_ECOLI] Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in bacteria and archaea that play important roles in the development of antibiotic resistance, a global health problem. Here we describe the crystal structure of the MarR protein, determined at a resolution of 2.3 A. This is the first reported crystal structure of a member of this newly-described protein family. The structure shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgs_consurf.spt"</scriptWhenChecked>
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1JGS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution., Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF, Nat Struct Biol. 2001 Aug;8(8):710-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11473263 11473263]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgs ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Alekshun, M N.]]
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[[Category: Alekshun MN]]
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[[Category: Head, J F.]]
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[[Category: Head JF]]
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[[Category: Levy, S B.]]
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[[Category: Levy SB]]
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[[Category: Mealy, T R.]]
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[[Category: Mealy TR]]
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[[Category: Seaton, B A.]]
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[[Category: Seaton BA]]
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[[Category: Antibiotic resistance]]
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[[Category: Dna-binding]]
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[[Category: Repressor]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:12:19 2008''
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Current revision

Multiple Antibiotic Resistance Repressor, MarR

PDB ID 1jgs

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