8flj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA== | |
| - | + | <StructureSection load='8flj' size='340' side='right'caption='[[8flj]], [[Resolution|resolution]] 3.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8flj]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PA14 Pseudomonas aeruginosa PA14] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FLJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FLJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.48Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8flj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8flj OCA], [https://pdbe.org/8flj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8flj RCSB], [https://www.ebi.ac.uk/pdbsum/8flj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8flj ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAS1_PSEAB CAS1_PSEAB] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Involved in the integration of spacer DNA into the CRISPR cassette (By similarity). Acts as a ss- and dsDNA-specific endonuclease.<ref>PMID:19523907</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa PA14]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Buyukyoruk M]] | ||
| + | [[Category: Eng ET]] | ||
| + | [[Category: Gauvin C]] | ||
| + | [[Category: Henriques WS]] | ||
| + | [[Category: Lander GC]] | ||
| + | [[Category: Neselu K]] | ||
| + | [[Category: Santiago-Frangos A]] | ||
| + | [[Category: Wiedenheft B]] | ||
| + | [[Category: Wiegand T]] | ||
Current revision
Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA
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