7xw9

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7xw9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XW9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7xw9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XW9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xw9 OCA], [https://pdbe.org/7xw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xw9 RCSB], [https://www.ebi.ac.uk/pdbsum/7xw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xw9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xw9 OCA], [https://pdbe.org/7xw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xw9 RCSB], [https://www.ebi.ac.uk/pdbsum/7xw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xw9 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Resistance to thyrotropin-releasing hormone syndrome. The disease is caused by variants affecting the gene represented in this entry.
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==See Also==
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== Function ==
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*[[Transducin 3D structures|Transducin 3D structures]]
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[https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.<ref>PMID:26735259</ref> <ref>PMID:9141550</ref>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>

Current revision

Cryo-EM structure of the TRH-bound human TRHR-Gq complex

PDB ID 7xw9

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