8c4g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Small molecule amidine soak in 14-3-3/ERa (AZ132)== | |
| - | + | <StructureSection load='8c4g' size='340' side='right'caption='[[8c4g]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c4g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C4G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KM8:~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]propanamide'>KM8</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c4g OCA], [https://pdbe.org/8c4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c4g RCSB], [https://www.ebi.ac.uk/pdbsum/8c4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c4g ProSAT]</span></td></tr> |
| - | [[Category: Ottmann | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ottmann C]] | ||
| + | [[Category: Sijbesma E]] | ||
| + | [[Category: Visser EJ]] | ||
Current revision
Small molecule amidine soak in 14-3-3/ERa (AZ132)
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