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8hun

From Proteopedia

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'''Unreleased structure'''
 
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The entry 8hun is ON HOLD
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==PDB entry title: X-ray structure of human PPAR alpha ligand binding domain-seladelpar co-crystals obtained by cross-seeding==
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<StructureSection load='8hun' size='340' side='right'caption='[[8hun]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KKB:Seladelpar'>KKB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hun OCA], [https://pdbe.org/8hun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hun RCSB], [https://www.ebi.ac.uk/pdbsum/8hun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hun ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
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Authors:
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==See Also==
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Honda A]]
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[[Category: Iino S]]
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[[Category: Ishii I]]
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[[Category: Kamata S]]
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[[Category: Machida Y]]
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[[Category: Masuda R]]
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[[Category: Oyama T]]
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[[Category: Shiiyama Y]]
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[[Category: Uchii K]]

Current revision

PDB entry title: X-ray structure of human PPAR alpha ligand binding domain-seladelpar co-crystals obtained by cross-seeding

PDB ID 8hun

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