1jlv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:40, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jlv.gif|left|200px]]
 
-
<!--
+
==Anopheles dirus species B glutathione S-transferases 1-3==
-
The line below this paragraph, containing "STRUCTURE_1jlv", creates the "Structure Box" on the page.
+
<StructureSection load='1jlv' size='340' side='right'caption='[[1jlv]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1jlv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JLV FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-
{{STRUCTURE_1jlv| PDB=1jlv | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlv OCA], [https://pdbe.org/1jlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jlv RCSB], [https://www.ebi.ac.uk/pdbsum/1jlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jlv ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q7KIF2_9DIPT Q7KIF2_9DIPT]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jl/1jlv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jlv ConSurf].
 +
<div style="clear:both"></div>
-
'''Anopheles dirus species B glutathione S-transferases 1-3'''
+
==See Also==
-
 
+
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
-
 
+
__TOC__
-
==Overview==
+
</StructureSection>
-
Glutathione S-transferases (GSTs) are dimeric proteins that play an important role in cellular detoxification. Four GSTs from the mosquito Anopheles dirus species B (Ad), an important malaria vector in South East Asia, are produced by alternate splicing of a single transcription product and were previously shown to have detoxifying activity towards pesticides such as DDT. We have determined the crystal structures for two of these alternatively spliced proteins, AdGST1-3 (complexed with glutathione) and AdGST1-4 (apo form), at 1.75 and 2.45 A resolution, respectively. These GST isozymes show differences from the related GST from the Australian sheep blowfly Lucilia cuprina; in particular, the presence of a C-terminal helix forming part of the active site. This helix causes the active site of the Anopheles GSTs to be enclosed. The glutathione-binding helix alpha2 and flanking residues are disordered in the AdGST1-4 (apo) structure, yet ordered in the AdGST1-3 (GSH-bound) structure, suggesting that insect GSTs operate with an induced fit mechanism similar to that found in the plant phi- and human pi-class GSTs. Despite the high overall sequence identities, the active site residues of AdGST1-4 and AdGST1-3 have different conformations.
+
-
 
+
-
==About this Structure==
+
-
1JLV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_cracens Anopheles cracens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JLV OCA].
+
-
 
+
-
==Reference==
+
-
The crystal structures of glutathione S-transferases isozymes 1-3 and 1-4 from Anopheles dirus species B., Oakley AJ, Harnnoi T, Udomsinprasert R, Jirajaroenrat K, Ketterman AJ, Wilce MC, Protein Sci. 2001 Nov;10(11):2176-85. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11604524 11604524]
+
[[Category: Anopheles cracens]]
[[Category: Anopheles cracens]]
-
[[Category: Glutathione transferase]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Harnnoi T]]
-
[[Category: Harnnoi, T.]]
+
[[Category: Jirajaroenrat K]]
-
[[Category: Jirajaroenrat, K.]]
+
[[Category: Ketterman AJ]]
-
[[Category: Ketterman, A J.]]
+
[[Category: Oakley AJ]]
-
[[Category: Oakley, A J.]]
+
[[Category: Udomsinprasert R]]
-
[[Category: Udomsinprasert, R.]]
+
[[Category: Wilce MC]]
-
[[Category: Wilce, M C.]]
+
-
[[Category: Adgst1-3]]
+
-
[[Category: Glutathione s-transferase]]
+
-
[[Category: Gst]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:23:00 2008''
+

Current revision

Anopheles dirus species B glutathione S-transferases 1-3

PDB ID 1jlv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jlv"
Personal tools