8bzq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Beta-1,4-D-endoglucanase Cel45A from Gloeophyllum trabeum== | |
| + | <StructureSection load='8bzq' size='340' side='right'caption='[[8bzq]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8bzq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeophyllum_trabeum_ATCC_11539 Gloeophyllum trabeum ATCC 11539]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BZQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BZQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bzq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bzq OCA], [https://pdbe.org/8bzq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bzq RCSB], [https://www.ebi.ac.uk/pdbsum/8bzq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bzq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/S7QB86_GLOTA S7QB86_GLOTA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Here we describe the first crystal structure of a beta-1,4-endoglucanase from a brown-rot fungus, Gloeophyllum trabeum GtCel45A, which belongs to subfamily C of glycoside hydrolase family 45 (GH45). GtCel45A is ~ 18 kDa in size and the crystal structure contains 179 amino acids. The structure is refined at 1.30 A resolution and R(free) 0.18. The enzyme consists of a single catalytic module folded into a six-stranded double-psi beta-barrel domain surrounded by long loops. GtCel45A is very similar in sequence (82% identity) and structure to PcCel45A from the white-rot fungus Phanerochaete chrysosporium. Surprisingly though, initial hydrolysis of barley beta-glucan was almost twice as fast in GtCel45A as compared to PcCel45A. | ||
| - | + | The first crystal structure of a family 45 glycoside hydrolase from a brown-rot fungus, Gloeophyllum trabeum GtCel45A.,Okmane L, Fitkin L, Sandgren M, Stahlberg J FEBS Open Bio. 2024 Mar;14(3):505-514. doi: 10.1002/2211-5463.13774. Epub 2024 , Feb 4. PMID:38311343<ref>PMID:38311343</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8bzq" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gloeophyllum trabeum ATCC 11539]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fitkin L]] | ||
| + | [[Category: Okmane L]] | ||
| + | [[Category: Stahlberg J]] | ||
Current revision
Beta-1,4-D-endoglucanase Cel45A from Gloeophyllum trabeum
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