1jnu

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[[Image:1jnu.gif|left|200px]]
 
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==Photoexcited structure of the plant photoreceptor domain, phy3 LOV2==
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The line below this paragraph, containing "STRUCTURE_1jnu", creates the "Structure Box" on the page.
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<StructureSection load='1jnu' size='340' side='right'caption='[[1jnu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jnu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Adiantum_capillus-veneris Adiantum capillus-veneris]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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{{STRUCTURE_1jnu| PDB=1jnu | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnu OCA], [https://pdbe.org/1jnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnu RCSB], [https://www.ebi.ac.uk/pdbsum/1jnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnu ProSAT]</span></td></tr>
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</table>
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'''Photoexcited structure of the plant photoreceptor domain, phy3 LOV2'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q9ZWQ6_ADICA Q9ZWQ6_ADICA]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The phototropins are flavoprotein kinases that control phototropic bending, light-induced chloroplast movement, and stomatal opening in plants. Two flavin mononucleotide binding light, oxygen, or voltage (LOV) domains are the sites for initial photochemistry in these blue light photoreceptors. We have determined the steady state, photoexcited crystal structure of a flavin-bound LOV domain. The structure reveals a unique photochemical switch in the flavin binding pocket in which the absorption of light drives the formation of a reversible covalent bond between a highly conserved Cys residue and the flavin cofactor. This provides a molecular picture of a cysteinyl-flavin covalent adduct, the presumed signaling species that leads to phototropin kinase activation and subsequent signal transduction. We identify closely related LOV domains in two eubacterial proteins that suggests the light-induced conformational change evident in this structure is an ancient biomolecular response to light, arising before the appearance of plants.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnu_consurf.spt"</scriptWhenChecked>
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1JNU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNU OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Photoexcited structure of a plant photoreceptor domain reveals a light-driven molecular switch., Crosson S, Moffat K, Plant Cell. 2002 May;14(5):1067-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12034897 12034897]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnu ConSurf].
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[[Category: Eukaryota]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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__TOC__
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[[Category: Crosson, S.]]
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</StructureSection>
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[[Category: Moffat, K.]]
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[[Category: Adiantum capillus-veneris]]
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[[Category: Cysteinyl-flavin adduct]]
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[[Category: Large Structures]]
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[[Category: Light-driven bond]]
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[[Category: Lov]]
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[[Category: Pa]]
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[[Category: Photochemistry]]
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[[Category: Photoexcited]]
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[[Category: Phototropin]]
[[Category: Phototropin]]
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[[Category: Phy3]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Plant photoreceptor]]
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[[Category: Crosson S]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:28:24 2008''
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[[Category: Moffat K]]

Current revision

Photoexcited structure of the plant photoreceptor domain, phy3 LOV2

PDB ID 1jnu

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