1jqn

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[[Image:1jqn.gif|left|200px]]
 
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==Crystal structure of E.coli phosphoenolpyruvate carboxylase in complex with Mn2+ and DCDP==
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The line below this paragraph, containing "STRUCTURE_1jqn", creates the "Structure Box" on the page.
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<StructureSection load='1jqn' size='340' side='right'caption='[[1jqn]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jqn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=DCO:3,3-DICHLORO-2-PHOSPHONOMETHYL-ACRYLIC+ACID'>DCO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_1jqn| PDB=1jqn | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqn OCA], [https://pdbe.org/1jqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqn RCSB], [https://www.ebi.ac.uk/pdbsum/1jqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPP_ECOLI CAPP_ECOLI] Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.[HAMAP-Rule:MF_00595]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jq/1jqn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jqn ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of E.coli phosphoenolpyruvate carboxylase in complex with Mn2+ and DCDP'''
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==See Also==
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*[[Phosphoenolpyruvate carboxylase|Phosphoenolpyruvate carboxylase]]
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__TOC__
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==Overview==
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</StructureSection>
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Phosphoenolpyruvate carboxylase (PEPC) catalyzes the first step in the fixation of atmospheric CO(2) during C(4) photosynthesis. The crystal structure of C(4) form maize PEPC (ZmPEPC), the first structure of the plant PEPCs, has been determined at 3.0 A resolution. The structure includes a sulfate ion at the plausible binding site of an allosteric activator, glucose 6-phosphate. The crystal structure of E. coli PEPC (EcPEPC) complexed with Mn(2+), phosphoenolpyruvate analog (3,3-dichloro-2-dihydroxyphosphinoylmethyl-2-propenoate), and an allosteric inhibitor, aspartate, has also been determined at 2.35 A resolution. Dynamic movements were found in the ZmPEPC structure, compared with the EcPEPC structure, around two loops near the active site. On the basis of these molecular structures, the mechanisms for the carboxylation reaction and for the allosteric regulation of PEPC are proposed.
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==About this Structure==
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1JQN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQN OCA].
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==Reference==
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Crystal structures of C4 form maize and quaternary complex of E. coli phosphoenolpyruvate carboxylases., Matsumura H, Xie Y, Shirakata S, Inoue T, Yoshinaga T, Ueno Y, Izui K, Kai Y, Structure. 2002 Dec;10(12):1721-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12467579 12467579]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Phosphoenolpyruvate carboxylase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Kai Y]]
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[[Category: Kai, Y.]]
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[[Category: Matsumura H]]
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[[Category: Matsumura, H.]]
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[[Category: Beta barrel]]
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[[Category: Mn2+ and dcdp complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:40:12 2008''
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Crystal structure of E.coli phosphoenolpyruvate carboxylase in complex with Mn2+ and DCDP

PDB ID 1jqn

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