1jr4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:41, 7 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jr4.jpg|left|200px]]
 
-
<!--
+
==CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX==
-
The line below this paragraph, containing "STRUCTURE_1jr4", creates the "Structure Box" on the page.
+
<StructureSection load='1jr4' size='340' side='right'caption='[[1jr4]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1jr4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JR4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL4:N-{3-[5-(6-AMINO-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YL]-ALLYL}-2,3-DIHYDROXY-5-NITRO-BENZAMIDE'>CL4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
{{STRUCTURE_1jr4| PDB=1jr4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jr4 OCA], [https://pdbe.org/1jr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jr4 RCSB], [https://www.ebi.ac.uk/pdbsum/1jr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jr4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jr/1jr4_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jr4 ConSurf].
 +
<div style="clear:both"></div>
-
'''CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX'''
+
==See Also==
-
 
+
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
-
 
+
__TOC__
-
==About this Structure==
+
</StructureSection>
-
1JR4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JR4 OCA].
+
[[Category: Large Structures]]
-
 
+
-
==Reference==
+
-
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann-La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing. , Lerner C, Ruf A, Gramlich V, Masjost B, Zurcher G, Jakob-Roetne R, Borroni E, Diederich F, Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4040-4042. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12404486 12404486]
+
-
[[Category: Catechol O-methyltransferase]]
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Single protein]]
+
[[Category: Ruf A]]
-
[[Category: Ruf, A.]]
+
[[Category: Stihle M]]
-
[[Category: Stihle, M.]]
+
-
[[Category: Bisubstrate inhibitor]]
+
-
[[Category: Methyltransferase]]
+
-
[[Category: Neurotransmitter degradation]]
+
-
[[Category: Transferase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:43:10 2008''
+

Current revision

CATECHOL O-METHYLTRANSFERASE BISUBSTRATE-INHIBITOR COMPLEX

PDB ID 1jr4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jr4"
Personal tools