8fy0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)== | |
| - | + | <StructureSection load='8fy0' size='340' side='right'caption='[[8fy0]], [[Resolution|resolution]] 2.94Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fy0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FY0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FY0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.94Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAD:CACODYLIC+ACID'>CAD</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=YF8:N-[8-(4-{[(1R,3R,4S)-4-(4-chlorophenyl)-1-methyl-3-{[4-(4-{[4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-(trifluoromethanesulfonyl)benzene-1-sulfonyl]carbamoyl}phenyl)piperazin-1-yl]methyl}cyclohexyl]methyl}piperazin-1-yl)-8-oxooctanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide'>YF8</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fy0 OCA], [https://pdbe.org/8fy0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fy0 RCSB], [https://www.ebi.ac.uk/pdbsum/8fy0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fy0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hromas R]] | ||
| + | [[Category: Hu W]] | ||
| + | [[Category: Lv D]] | ||
| + | [[Category: Lv Z]] | ||
| + | [[Category: Nayak D]] | ||
| + | [[Category: Olsen SK]] | ||
| + | [[Category: Sung P]] | ||
| + | [[Category: Yuan Y]] | ||
| + | [[Category: Zhang P]] | ||
| + | [[Category: Zheng G]] | ||
| + | [[Category: Zhou D]] | ||
Current revision
E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL)
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Categories: Homo sapiens | Large Structures | Hromas R | Hu W | Lv D | Lv Z | Nayak D | Olsen SK | Sung P | Yuan Y | Zhang P | Zheng G | Zhou D
