1jsw

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[[Image:1jsw.gif|left|200px]]
 
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==NATIVE L-ASPARTATE AMMONIA LYASE==
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The line below this paragraph, containing "STRUCTURE_1jsw", creates the "Structure Box" on the page.
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<StructureSection load='1jsw' size='340' side='right'caption='[[1jsw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jsw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_B Escherichia coli B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene></td></tr>
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{{STRUCTURE_1jsw| PDB=1jsw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jsw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsw OCA], [https://pdbe.org/1jsw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jsw RCSB], [https://www.ebi.ac.uk/pdbsum/1jsw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jsw ProSAT]</span></td></tr>
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</table>
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'''NATIVE L-ASPARTATE AMMONIA LYASE'''
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== Function ==
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[https://www.uniprot.org/uniprot/ASPA_ECOLI ASPA_ECOLI]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The X-ray crystal structure of l-aspartate ammonia-lyase has been determined to 2.8 A resolution. The enzyme contains three domains, and each domain is composed almost completely of alpha helices. The central domain is composed of five long helices. In the tetramer, these five helices form a 20-helix cluster. Such clusters have also been seen in delta-crystallin and in fumarase. The active site of aspartase has been located in a region that contains side chains from three different subunits. The structure of the apoenzyme has made it possible to identify some of the residues that are involved in binding the substrate. These residues have been examined by site-directed mutagenesis, and their putative roles have been assigned [Jayasekera, M. M. K., Shi, W., Farber, G. K., &amp; Viola, R. E. (1997) Biochemistry 36, 9145-9150].
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsw_consurf.spt"</scriptWhenChecked>
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1JSW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSW OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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The structure of L-aspartate ammonia-lyase from Escherichia coli., Shi W, Dunbar J, Jayasekera MM, Viola RE, Farber GK, Biochemistry. 1997 Jul 29;36(30):9136-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9230045 9230045]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jsw ConSurf].
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[[Category: Aspartate ammonia-lyase]]
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<div style="clear:both"></div>
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[[Category: Escherichia coli]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Dunbar, J.]]
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[[Category: Escherichia coli B]]
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[[Category: Farber, G K.]]
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[[Category: Large Structures]]
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[[Category: Shi, W.]]
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[[Category: Dunbar J]]
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[[Category: Amino acid ammonia-lyase]]
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[[Category: Farber GK]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:52:00 2008''
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[[Category: Shi W]]

Current revision

NATIVE L-ASPARTATE AMMONIA LYASE

PDB ID 1jsw

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