8cdx
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8cdx is ON HOLD Authors: Angeli, A., Ferraroni, M. Description: Human carbonic anhydrase I complexed with 4-(3-ethylureido)benzenesulfonamide [[Cat...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human carbonic anhydrase I complexed with 4-(3-ethylureido)benzenesulfonamide== | |
| + | <StructureSection load='8cdx' size='340' side='right'caption='[[8cdx]], [[Resolution|resolution]] 1.33Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8cdx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CDX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CDX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.335Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cdx OCA], [https://pdbe.org/8cdx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cdx RCSB], [https://www.ebi.ac.uk/pdbsum/8cdx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cdx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAH1_HUMAN CAH1_HUMAN] Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea.<ref>PMID:10550681</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Sulfonamides remain an important class of drugs, especially because of their inhibitory effects on carbonic anhydrases. Herein, we have synthesized several sulfonamides and tested them for their inhibitory activity against carbonic anhydrases hCA I, hCA II, hCA IX, and hCA XII, respectively. Thereby, biphenyl- and benzylphenyl-substituted sulfonamides showed high selectivity against hCA IX and hCA XII; these enzymes are common targets in the treatment of hypoxic cancers, and noteworthy inhibitory activity was observed for several compounds toward hCA I that might be of interest for future applications to treat cerebral edema. Compound 3 (4-[3-(2-benzylphenyl)ureido]benzenesulfonamide) held an exceptionally low K(i) value of 1.0 nM for hCA XII. | ||
| - | + | Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors.,Denner TC, Angeli A, Ferraroni M, Supuran CT, Csuk R Molecules. 2023 Nov 26;28(23):7782. doi: 10.3390/molecules28237782. PMID:38067512<ref>PMID:38067512</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Angeli | + | <div class="pdbe-citations 8cdx" style="background-color:#fffaf0;"></div> |
| - | [[Category: Ferraroni | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Angeli A]] | ||
| + | [[Category: Ferraroni M]] | ||
Current revision
Human carbonic anhydrase I complexed with 4-(3-ethylureido)benzenesulfonamide
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