This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8ce9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8ce9 is ON HOLD Authors: Koekemoer, L., Williams, E., Ni, X., Gao, Q., Coker, J., MacLean, E.M., Wright, N.D., Marsden, B., Von Delft, F., Schwenzer...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Cd11b I domain in C121 space group== | |
| - | + | <StructureSection load='8ce9' size='340' side='right'caption='[[8ce9]], [[Resolution|resolution]] 2.11Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ce9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CE9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ce9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ce9 OCA], [https://pdbe.org/8ce9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ce9 RCSB], [https://www.ebi.ac.uk/pdbsum/8ce9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ce9 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Ni | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Coker J]] |
| - | [[Category: | + | [[Category: Gao Q]] |
| + | [[Category: Koekemoer L]] | ||
| + | [[Category: MacLean EM]] | ||
| + | [[Category: Marsden B]] | ||
| + | [[Category: Midwood K]] | ||
| + | [[Category: Ni X]] | ||
| + | [[Category: Schwenzer A]] | ||
| + | [[Category: Von Delft F]] | ||
| + | [[Category: Williams E]] | ||
| + | [[Category: Wright ND]] | ||
Current revision
Crystal structure of human Cd11b I domain in C121 space group
| |||||||||||
Categories: Homo sapiens | Large Structures | Coker J | Gao Q | Koekemoer L | MacLean EM | Marsden B | Midwood K | Ni X | Schwenzer A | Von Delft F | Williams E | Wright ND
