This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8cew
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8cew is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human DNA cross-link repair 1A in complex with N-hydroxyimide inhibitor H1== | |
| - | + | <StructureSection load='8cew' size='340' side='right'caption='[[8cew]], [[Resolution|resolution]] 1.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8cew]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CEW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CEW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=UFI:6-methoxy-2-oxidanyl-benzo[de]isoquinoline-1,3-dione'>UFI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cew OCA], [https://pdbe.org/8cew PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cew RCSB], [https://www.ebi.ac.uk/pdbsum/8cew PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cew ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DCR1A_HUMAN DCR1A_HUMAN] May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.<ref>PMID:15542852</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baddock HT]] | ||
| + | [[Category: Bielinski M]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Gileadi O]] | ||
| + | [[Category: McHugh PJ]] | ||
| + | [[Category: Newman JA]] | ||
| + | [[Category: Schofield CJ]] | ||
| + | [[Category: Yosaatmadja Y]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Crystal structure of human DNA cross-link repair 1A in complex with N-hydroxyimide inhibitor H1
| |||||||||||
