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8fz0

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m (Protected "8fz0" [edit=sysop:move=sysop])
Current revision (05:43, 31 May 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8fz0 is ON HOLD
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==Cryo-EM Structure of empty AAV2 capsid==
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<StructureSection load='8fz0' size='340' side='right'caption='[[8fz0]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
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Authors: Bennett, A.D., McKenna, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8fz0]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_2 Adeno-associated virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FZ0 FirstGlance]. <br>
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Description: Cryo-EM Structure of empty AAV2 capsid
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fz0 OCA], [https://pdbe.org/8fz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fz0 RCSB], [https://www.ebi.ac.uk/pdbsum/8fz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fz0 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Bennett, A.D]]
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== Function ==
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[[Category: Mckenna, R]]
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[https://www.uniprot.org/uniprot/CAPSD_AAV2S CAPSD_AAV2S] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.<ref>PMID:10684294</ref> <ref>PMID:11961250</ref> <ref>PMID:16940508</ref> <ref>PMID:9445046</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Adeno-associated virus 2]]
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[[Category: Large Structures]]
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[[Category: Bennett AD]]
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[[Category: McKenna R]]

Current revision

Cryo-EM Structure of empty AAV2 capsid

PDB ID 8fz0

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