8fzc
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==HIV-2 Gag Capsid from Immature Virus-like Particles== | |
| - | + | <StructureSection load='8fzc' size='340' side='right'caption='[[8fzc]], [[Resolution|resolution]] 5.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fzc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_2_(ISOLATE_ROD) Human immunodeficiency virus type 2 (ISOLATE ROD)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FZC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.5Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fzc OCA], [https://pdbe.org/8fzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fzc RCSB], [https://www.ebi.ac.uk/pdbsum/8fzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fzc ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GAG_HV2RO GAG_HV2RO] Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity). p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mansky LM]] | ||
| + | [[Category: Talledge N]] | ||
| + | [[Category: Zhang W]] | ||
Current revision
HIV-2 Gag Capsid from Immature Virus-like Particles
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