8g2k
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8g2k is ON HOLD Authors: Venkatramani, L., Mooers, B.H.M., Air, G.M. Description: Structure of the H3 hemagglutinin of A/California/7/2004 [[Catego...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the H3 hemagglutinin of A/California/7/2004== | |
| - | + | <StructureSection load='8g2k' size='340' side='right'caption='[[8g2k]], [[Resolution|resolution]] 2.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8g2k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Alphainfluenzavirus_influenzae Alphainfluenzavirus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G2K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g2k OCA], [https://pdbe.org/8g2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g2k RCSB], [https://www.ebi.ac.uk/pdbsum/8g2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g2k ProSAT]</span></td></tr> |
| - | [[Category: Air | + | </table> |
| - | [[Category: Mooers | + | == Function == |
| + | [https://www.uniprot.org/uniprot/H9XN76_9INFA H9XN76_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Alphainfluenzavirus influenzae]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Air GM]] | ||
| + | [[Category: Mooers BHM]] | ||
| + | [[Category: Venkatramani L]] | ||
Current revision
Structure of the H3 hemagglutinin of A/California/7/2004
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