8ia5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8ia5 is ON HOLD Authors: Cheng, X.Y., Wei, Q.Y., Huang, Y., Su, Z.D. Description: Small peptide enhances the binding of nutline-3a to N-terminal do...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX== | |
| + | <StructureSection load='8ia5' size='340' side='right'caption='[[8ia5]], [[Resolution|resolution]] 1.93Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8ia5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IA5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NUT:4-({(4S,5R)-4,5-BIS(4-CHLOROPHENYL)-2-[4-METHOXY-2-(PROPAN-2-YLOXY)PHENYL]-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}CARBONYL)PIPERAZIN-2-ONE'>NUT</scene>, <scene name='pdbligand=O4B:1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE'>O4B</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ia5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ia5 OCA], [https://pdbe.org/8ia5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ia5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ia5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ia5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[MDM4|MDM4]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Huang | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Wei | + | [[Category: Large Structures]] |
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Cheng XY]] | ||
| + | [[Category: Huang Y]] | ||
| + | [[Category: Su ZD]] | ||
| + | [[Category: Wei QY]] | ||
Current revision
Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX
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