1jwc

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[[Image:1jwc.gif|left|200px]]
 
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==NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1jwc", creates the "Structure Box" on the page.
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<StructureSection load='1jwc' size='340' side='right'caption='[[1jwc]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jwc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JWC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jwc OCA], [https://pdbe.org/1jwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jwc RCSB], [https://www.ebi.ac.uk/pdbsum/1jwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jwc ProSAT]</span></td></tr>
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{{STRUCTURE_1jwc| PDB=1jwc | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN'''
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== Publication Abstract from PubMed ==
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==Overview==
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The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP), that is involved in multiple aspects of histone mRNA metabolism and regulation. We have determined the structure of the 26-nt sequence by multidimensional NMR spectroscopy. There is a 16-nt stem-loop motif, with a conserved 6-bp stem and a 4-nt loop. The loop is closed by a conserved U.A base pair that terminates the canonical A-form stem. The pyrimidine-rich 4-nt loop, UUUC, is well organized with the three uridines stacking on the helix, and the fourth base extending across the major groove into the solvent. The flanking nucleotides at the base of the hairpin stem do not assume a unique conformation, despite the fact that the 5' flanking nucleotides are a critical component of the SLBP binding site.
The 3' end of replication-dependent histone mRNAs terminate in a conserved sequence containing a stem-loop. This 26-nt sequence is the binding site for a protein, stem-loop binding protein (SLBP), that is involved in multiple aspects of histone mRNA metabolism and regulation. We have determined the structure of the 26-nt sequence by multidimensional NMR spectroscopy. There is a 16-nt stem-loop motif, with a conserved 6-bp stem and a 4-nt loop. The loop is closed by a conserved U.A base pair that terminates the canonical A-form stem. The pyrimidine-rich 4-nt loop, UUUC, is well organized with the three uridines stacking on the helix, and the fourth base extending across the major groove into the solvent. The flanking nucleotides at the base of the hairpin stem do not assume a unique conformation, despite the fact that the 5' flanking nucleotides are a critical component of the SLBP binding site.
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==About this Structure==
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NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein.,DeJong ES, Marzluff WF, Nikonowicz EP RNA. 2002 Jan;8(1):83-96. PMID:11871662<ref>PMID:11871662</ref>
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1JWC is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWC OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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NMR structure and dynamics of the RNA-binding site for the histone mRNA stem-loop binding protein., DeJong ES, Marzluff WF, Nikonowicz EP, RNA. 2002 Jan;8(1):83-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11871662 11871662]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 1jwc" style="background-color:#fffaf0;"></div>
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[[Category: Dejong, E S.]]
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== References ==
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[[Category: Marzluff, W F.]]
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<references/>
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[[Category: Nikonowicz, E P.]]
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__TOC__
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[[Category: 3' stack]]
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</StructureSection>
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[[Category: Hairpin]]
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[[Category: Large Structures]]
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[[Category: Tetraloop]]
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[[Category: Mus musculus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:00:18 2008''
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[[Category: Dejong ES]]
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[[Category: Marzluff WF]]
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[[Category: Nikonowicz EP]]

Current revision

NMR SOLUTION STRUCTURE OF THE RNA HAIRPIN BINDING SITE FOR THE HISTONE STEM-LOOP BINDING PROTEIN

PDB ID 1jwc

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