1jwo

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[[Image:1jwo.jpg|left|200px]]
 
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==Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK==
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The line below this paragraph, containing "STRUCTURE_1jwo", creates the "Structure Box" on the page.
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<StructureSection load='1jwo' size='340' side='right'caption='[[1jwo]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jwo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JWO FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jwo OCA], [https://pdbe.org/1jwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jwo RCSB], [https://www.ebi.ac.uk/pdbsum/1jwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jwo ProSAT]</span></td></tr>
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{{STRUCTURE_1jwo| PDB=1jwo | SCENE= }}
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</table>
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== Function ==
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'''Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK'''
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[https://www.uniprot.org/uniprot/MATK_HUMAN MATK_HUMAN] Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.<ref>PMID:9171348</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1JWO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JWO OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/1jwo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jwo ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Murthy TVS]]
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[[Category: Murthy, T V.S.]]
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[[Category: Webster GD]]
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[[Category: Webster, G D.]]
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[[Category: Antiparallel beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:01:06 2008''
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Current revision

Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK

PDB ID 1jwo

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