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1jxc

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[[Image:1jxc.gif|left|200px]]
 
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==Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor==
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The line below this paragraph, containing "STRUCTURE_1jxc", creates the "Structure Box" on the page.
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<StructureSection load='1jxc' size='340' side='right'caption='[[1jxc]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JXC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jxc OCA], [https://pdbe.org/1jxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jxc RCSB], [https://www.ebi.ac.uk/pdbsum/1jxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jxc ProSAT], [https://www.topsan.org/Proteins/CESG/1jxc TOPSAN]</span></td></tr>
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{{STRUCTURE_1jxc| PDB=1jxc | SCENE= }}
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</table>
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== Function ==
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'''Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor'''
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[https://www.uniprot.org/uniprot/DF195_ARATH DF195_ARATH]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The three-dimensional structure of the precursor form of the Arabidopsis thaliana trypsin inhibitor (ATT(p), GenBank entry Z46816), a 68-residue (approximately 7.5 kDa) rapeseed class proteinase inhibitor, has been determined in solution at pH 5.0 and 25 degrees C by multinuclear magnetic resonance spectroscopy. The protein contains one alpha-helix and two strands of antiparallel beta-sheet, with a type IV beta-turn connecting the two strands. The alpha-helix and the inhibitory loop are connected to the beta-sheet through three disulfide bridges; a fourth disulfide bridge connects the N- and C-termini. The overall structural topology of ATT(p) is similar to those of the sweet tasting protein brazzein (rmsd of 3.0 A) and the antifungal protein Rs-Afp1 [a knottin protein from radish (Raphanus sativus), rmsd of 2.7 A]. The precursor segment in ATT(p) is disordered, as visualized by the final 20-conformer ensemble and as confirmed by (15)N heteronuclear NOE analysis. The overall fold of ATT(p) is distinct from those of other classes of serine proteinase inhibitors except in the inhibitor loop; therefore, it represents a new inhibitor fold.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jxc_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1JXC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JXC OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jxc ConSurf].
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NMR solution structure of ATTp, an Arabidopsis thaliana trypsin inhibitor., Zhao Q, Chae YK, Markley JL, Biochemistry. 2002 Oct 15;41(41):12284-96. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12369816 12369816]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Chae YK]]
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[[Category: Chae, Y K.]]
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[[Category: Markley JL]]
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[[Category: Markley, J L.]]
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[[Category: Zhao Q]]
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[[Category: Zhao, Q.]]
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[[Category: Att]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
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[[Category: Chymotrypsin inhibitor]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Protein structure initiative]]
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[[Category: Structural genomic]]
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[[Category: Trypsin inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:02:23 2008''
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Current revision

Minimized NMR structure of ATT, an Arabidopsis trypsin/chymotrypsin inhibitor

PDB ID 1jxc

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