From Proteopedia
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| - | | + | #REDIRECT [[6hl1]] This PDB entry is obsolete and replaced by 6hl1 |
| - | ==FXR with CDCA and NCoA-2 peptide==
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| - | <StructureSection load='4qe6' size='340' side='right'caption='[[4qe6]], [[Resolution|resolution]] 1.65Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4qe6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QE6 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JN3:CHENODEOXYCHOLIC+ACID'>JN3</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qe6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qe6 OCA], [https://pdbe.org/4qe6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qe6 RCSB], [https://www.ebi.ac.uk/pdbsum/4qe6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qe6 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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| - | ==See Also==
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| - | *[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Homo sapiens]]
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| - | [[Category: Large Structures]]
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| - | [[Category: Bamberg K]]
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| - | [[Category: Dekker N]]
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| - | [[Category: Kudlinzki D]]
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| - | [[Category: Linhard VL]]
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| - | [[Category: Merk D]]
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| - | [[Category: Nilsson E]]
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| - | [[Category: Saxena K]]
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| - | [[Category: Schubert-Zsilavecz M]]
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| - | [[Category: Schwalbe H]]
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| - | [[Category: Sreeramulu S]]
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| - | [[Category: Wissler L]]
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Current revision
- REDIRECT 6hl1 This PDB entry is obsolete and replaced by 6hl1
