8g69
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8g69 is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Wildtype PTP1b in complex with DES5743== | |
| + | <StructureSection load='8g69' size='340' side='right'caption='[[8g69]], [[Resolution|resolution]] 1.53Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8g69]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G69 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=YXN:4-(5-ethyl-3-methyl-1H-pyrazol-1-yl)aniline'>YXN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g69 OCA], [https://pdbe.org/8g69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g69 RCSB], [https://www.ebi.ac.uk/pdbsum/8g69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g69 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Giordanetto F]] | ||
| + | [[Category: Greisman JB]] | ||
| + | [[Category: Maragakis P]] | ||
| + | [[Category: Nisonoff H]] | ||
| + | [[Category: Shahamadtar S]] | ||
| + | [[Category: Shaw DE]] | ||
| + | [[Category: Willmore L]] | ||
| + | [[Category: Yeh CY]] | ||
Current revision
Wildtype PTP1b in complex with DES5743
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