User:Sloan August/Sandbox 1

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=SHOC2-PP1C-MRAS PROTEIN COMPLEX=
=SHOC2-PP1C-MRAS PROTEIN COMPLEX=
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<StructureSection load='7UPI' size='350' frame='true' side='right' caption='SHOC2-PP1C-MRAS Holophosphatase Complex' scene=’95/954044/Shoc2_switch_i_region/1’>
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<StructureSection load='7UPI' size='350' frame='true' side='right' caption='SHOC2-PP1C-MRAS Holophosphatase Complex'>
This is a default text for your page '''Sloan August/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page '''Sloan August/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==
== Function ==
<scene name='95/954044/Shoc2_switch_i_region/1'>SHOC2 Switch I Region</scene>
<scene name='95/954044/Shoc2_switch_i_region/1'>SHOC2 Switch I Region</scene>
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===Disease===
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=== Disease ===
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[[Image:SHOC2.png|350 px|center|thumb|Figure 1]]
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[[Image:RAF.jpg|350 px|center|thumb|Figure 1]]
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[[Image:pic3.jpg|350 px|center|thumb|Figure 1]]
== Relevance ==
== Relevance ==
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===Mechanism of SHOC2-PP1C-MRAS Complex Formation===
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=== Mechanism of SHOC2-PP1C-MRAS Complex Formation ===
[https://www.nature.com/articles/d41586-022-02189-7 Mechanistic Overview and Signaling Cascade ]
[https://www.nature.com/articles/d41586-022-02189-7 Mechanistic Overview and Signaling Cascade ]
== Structural highlights ==
== Structural highlights ==
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[[Image:Binding.png|400 px|right|thumb|Figure 1]]
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[[Image:Binding.png|400 px|left|thumb|Figure 1]]
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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Figure 1: MRAS binding sites
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<scene name='95/954044/Shoc2_gtp_bound_vs_unbound/2'>SHOC2 GTP Bound vs Unbound</scene>
</StructureSection>
</StructureSection>
== References ==
== References ==
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<ref name=”Ransey”>PMID:28504306</ref>.
<references/>
<references/>
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==Student Contributors==
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*Sloan August

Current revision

SHOC2-PP1C-MRAS PROTEIN COMPLEX

SHOC2-PP1C-MRAS Holophosphatase Complex

Drag the structure with the mouse to rotate

References

[3].

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677

Student Contributors

  • Sloan August

Proteopedia Page Contributors and Editors (what is this?)

Sloan August

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