User:Reagann R. Meyers/ Sandbox 1
From Proteopedia
< User:Reagann R. Meyers(Difference between revisions)
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==SHOC-2 PP1C MRAS== | ==SHOC-2 PP1C MRAS== | ||
| - | <StructureSection load=' | + | <StructureSection load='7upi' size='350' frame='true' side='right' caption='SHOC2-PP1C-MRAS' scene=''> |
| + | <ref name= "Strucuture">PMID:35831509</ref> | ||
| + | |||
| + | <scene name='95/954077/Random_residues/3'>Outer View of Random Residues</scene> | ||
| + | |||
This is a default text for your page '''Reagann R. Meyers/ Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Reagann R. Meyers/ Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | + | ==Strucutre== | |
| + | [[Image:thumbnail_PyMOL_MRAS_PP1Cpic.png|400 px|right|thumb|Figure 1. The coolest image of this protein.]] | ||
| + | ===Binding Site=== | ||
| + | <scene name='95/954077/Random_residues/4'>Random Residues</scene> | ||
== Function == | == Function == | ||
| - | + | ===Overall Function=== | |
| + | ===SHOC2-PP1C-MRAS Specifically=== | ||
| + | <ref name="Ransey">PMID:28504306</ref> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.mayoclinic.org/diseases-conditions/noonan-syndrome/symptoms-causes/syc-20354422#:~:text=Noonan%20syndrome%20is%20a%20genetic,problems%20and%20possible%20developmental%20delays. Noonan Disease] | |
== Relevance == | == Relevance == | ||
| + | <scene name='95/954077/Gdp_with_mras_and_shoc2/1'>TextToBeDisplayed</scene> | ||
== Structural highlights == | == Structural highlights == | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
| + | <scene name='95/952705/Switch_i_and_ii_with_gtp/5'>(Switch I and II with GTP)</scene>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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SHOC-2 PP1C MRAS
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References
- ↑ Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. 2022 Jul 13. pii: 10.1038/s41586-022-04928-2. doi:, 10.1038/s41586-022-04928-2. PMID:35831509 doi:http://dx.doi.org/10.1038/s41586-022-04928-2
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
