8g88
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human Oct4 bound to nucleosome with human nMatn1 sequence== | |
| + | <StructureSection load='8g88' size='340' side='right'caption='[[8g88]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8g88]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G88 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g88 OCA], [https://pdbe.org/8g88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g88 RCSB], [https://www.ebi.ac.uk/pdbsum/8g88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g88 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||
| - | + | ==See Also== | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Bilokapic S]] | ||
| + | [[Category: Du Y]] | ||
| + | [[Category: Halic M]] | ||
| + | [[Category: Malik D]] | ||
| + | [[Category: Sinha KK]] | ||
Current revision
Human Oct4 bound to nucleosome with human nMatn1 sequence
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Categories: Homo sapiens | Large Structures | Xenopus laevis | Bilokapic S | Du Y | Halic M | Malik D | Sinha KK
