8g8r
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8g8r is ON HOLD Authors: Tsimbslyuk, S., Stewart, M., Forwood, J.K. Description: RelB NLS in complex with Importin alpha 2 [[Category: Unreleased S...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==RelB NLS in complex with Importin alpha 2== | |
| - | + | <StructureSection load='8g8r' size='340' side='right'caption='[[8g8r]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8g8r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G8R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> |
| - | [[Category: Forwood | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g8r OCA], [https://pdbe.org/8g8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g8r RCSB], [https://www.ebi.ac.uk/pdbsum/8g8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g8r ProSAT]</span></td></tr> |
| - | [[Category: Stewart | + | </table> |
| - | [[Category: Tsimbslyuk | + | == Function == |
| + | [https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Forwood JK]] | ||
| + | [[Category: Stewart M]] | ||
| + | [[Category: Tsimbslyuk S]] | ||
Current revision
RelB NLS in complex with Importin alpha 2
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