1k2l

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[[Image:1k2l.gif|left|200px]]
 
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==STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX==
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The line below this paragraph, containing "STRUCTURE_1k2l", creates the "Structure Box" on the page.
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<StructureSection load='1k2l' size='340' side='right'caption='[[1k2l]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k2l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K2L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDC:BIS-(9-OCTYLAMINO(2-DIMETHYLAMINOETHYL)ACRIDINE-4-CARBOXAMIDE'>BDC</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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{{STRUCTURE_1k2l| PDB=1k2l | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2l OCA], [https://pdbe.org/1k2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k2l RCSB], [https://www.ebi.ac.uk/pdbsum/1k2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k2l ProSAT]</span></td></tr>
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</table>
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'''STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Adams A]]
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We report the single-crystal X-ray structure for the complex of the bisacridine bis-(9-aminooctyl(2-(dimethylaminoethyl)acridine-4-carboxamide)) with the oligonucleotide d(CGTACG)(2) to a resolution of 2.4A. Solution studies with closed circular DNA show this compound to be a bisintercalating threading agent, but so far we have no crystallographic or NMR structural data conforming to the model of contiguous intercalation within the same duplex. Here, with the hexameric duplex d(CGTACG), the DNA is observed to undergo a terminal cytosine base exchange to yield an unusual guanine quadruplex intercalation site through which the bisacridine threads its octamethylene linker to fuse two DNA duplexes. The 4-carboxamide side-chains form anchoring hydrogen-bonding interactions with guanine O6 atoms on each side of the quadruplex. This higher-order DNA structure provides insight into an unexpected property of bisintercalating threading agents, and suggests the idea of targeting such compounds specifically at four-way DNA junctions.
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[[Category: Cardin CJ]]
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[[Category: Denny WA]]
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==About this Structure==
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[[Category: Powell HR]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2L OCA].
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[[Category: Teixeira SCM]]
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[[Category: Thorpe JH]]
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==Reference==
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[[Category: Todd AK]]
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Structural characterisation of bisintercalation in higher-order DNA at a junction-like quadruplex., Teixeira SC, Thorpe JH, Todd AK, Powell HR, Adams A, Wakelin LP, Denny WA, Cardin CJ, J Mol Biol. 2002 Oct 18;323(2):167-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12381312 12381312]
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[[Category: Wakelin LPG]]
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[[Category: Adams, A.]]
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[[Category: Cardin, C J.]]
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[[Category: Denny, W A.]]
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[[Category: Powell, H R.]]
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[[Category: Teixeira, S C.M.]]
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[[Category: Thorpe, J H.]]
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[[Category: Todd, A K.]]
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[[Category: Wakelin, L P.G.]]
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[[Category: Bisintercalation]]
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[[Category: Dna strand exchange]]
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[[Category: Quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:13:29 2008''
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Current revision

STRUCTURAL CHARACTERIZATION OF BISINTERCALATION IN HIGHER-ORDER DNA AT A JUNCTION-LIKE QUADRUPLEX

PDB ID 1k2l

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