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8ceg

From Proteopedia

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Current revision (08:52, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ceg is ON HOLD until Paper Publication
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==BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling==
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<StructureSection load='8ceg' size='340' side='right'caption='[[8ceg]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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Authors: Kajander, T., Fudo, S., Yan, Z., Zhao, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ceg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CEG FirstGlance]. <br>
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Description: BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ceg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ceg OCA], [https://pdbe.org/8ceg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ceg RCSB], [https://www.ebi.ac.uk/pdbsum/8ceg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ceg ProSAT]</span></td></tr>
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[[Category: Kajander, T]]
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</table>
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[[Category: Fudo, S]]
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== Disease ==
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[[Category: Zhao, H]]
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[https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Postaxial polydactyly type A. The disease may be caused by variants affecting the gene represented in this entry.
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[[Category: Yan, Z]]
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== Function ==
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[https://www.uniprot.org/uniprot/CBAR1_HUMAN CBAR1_HUMAN] Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:27528616, PubMed:30395363). In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616, PubMed:30395363). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (PubMed:30404948). In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (PubMed:30404948).[UniProtKB:Q8BP22]<ref>PMID:27528616</ref> <ref>PMID:30395363</ref> <ref>PMID:30404948</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Fudo S]]
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[[Category: Kajander T]]
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[[Category: Yan Z]]
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[[Category: Zhao H]]

Current revision

BAR domain protein FAM92A1 essential for mitochondrial membrane remodeling

PDB ID 8ceg

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