2n99
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2n99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N99 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2n99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N99 FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n99 OCA], [https://pdbe.org/2n99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n99 RCSB], [https://www.ebi.ac.uk/pdbsum/2n99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n99 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n99 OCA], [https://pdbe.org/2n99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n99 RCSB], [https://www.ebi.ac.uk/pdbsum/2n99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n99 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/SLUR2_HUMAN SLUR2_HUMAN] Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner.<ref>PMID:16575903</ref> <ref>PMID:27485575</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Solution structure of the SLURP-2, a secreted isoform of Lynx1
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