User:Grace Lane/Sandbox 1

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==The Human Thyroid Stimulating Hormone Receptor==
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<scene name='95/957609/Transmembrane_region/1'>Text To Be Displayed</scene>==The Human Thyroid Stimulating Hormone Receptor==
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='7xw5' size='400' side='right' caption='Structure of the human thyroid stimulating hormone receptor bound to the thyrotropin. The G-proteins are also bound to the receptor' scene=''>
This is a default text for your page '''Grace Lane/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page '''Grace Lane/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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<scene name='95/957609/Transmembrane_region/1'>Transmembrane Region of TSHR</scene>
== Introduction ==
== Introduction ==
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[https://www.nature.com/articles/s41586-022-05159-1 Autoantibody mimicry of hormone action at the thyrotropin receptor]
[https://www.nature.com/articles/s41586-022-05159-1 Autoantibody mimicry of hormone action at the thyrotropin receptor]
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<Structure load='7XW5' size='400' frame='true' align='right' caption='Human Thyroid Stimulating Hormone Receptor' scene='Insert optional scene name here' />
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Practice Reference <ref name=”Ransey”>PMID:28504306</ref>.
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Autoantibody mimicry of hormone action at the thyrotropin receptor <ref>DOI 10.1038/s41586-022-05159-1</ref>
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Hormone- and antibody-mediated activation of the thyrotropin receptor <ref>DOI 0.1038/s41586-022-05173-3</ref>
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== Function ==
== Function ==

Current revision

==The Human Thyroid Stimulating Hormone Receptor==

Structure of the human thyroid stimulating hormone receptor bound to the thyrotropin. The G-proteins are also bound to the receptor

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
  4. ↑ Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature. 2022 Aug 8. pii: 10.1038/s41586-022-05159-1. doi:, 10.1038/s41586-022-05159-1. PMID:35940205 doi:http://dx.doi.org/10.1038/s41586-022-05159-1
  5. ↑ doi: https://dx.doi.org/0.1038/s41586-022-05173-3

Student Contributors

  • Grace Lane

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Grace Lane

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