8c53

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Current revision (10:03, 17 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8c53 is ON HOLD until Paper Publication
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==Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; CrystFEL processing==
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<StructureSection load='8c53' size='340' side='right'caption='[[8c53]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Lahey-Rudolph, J.M., Schoenherr, R., Boger, J., Harms, M., Kaiser, J., Nachtschatt, S., Wobbe, M., Duden, R., Bourenkov, G., Schneider, T., Redecke, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8c53]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C53 FirstGlance]. <br>
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Description: Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; CrystFEL processing
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Schoenherr, R]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c53 OCA], [https://pdbe.org/8c53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c53 RCSB], [https://www.ebi.ac.uk/pdbsum/8c53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c53 ProSAT]</span></td></tr>
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[[Category: Redecke, L]]
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</table>
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[[Category: Harms, M]]
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== Function ==
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[[Category: Schneider, T]]
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[https://www.uniprot.org/uniprot/IMDH_TRYBB IMDH_TRYBB] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
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[[Category: Bourenkov, G]]
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__TOC__
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[[Category: Wobbe, M]]
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</StructureSection>
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[[Category: Nachtschatt, S]]
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[[Category: Large Structures]]
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[[Category: Boger, J]]
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[[Category: Trypanosoma brucei]]
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[[Category: Kaiser, J]]
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[[Category: Boger J]]
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[[Category: Lahey-Rudolph, J.M]]
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[[Category: Bourenkov G]]
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[[Category: Duden, R]]
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[[Category: Duden R]]
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[[Category: Harms M]]
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[[Category: Kaiser J]]
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[[Category: Lahey-Rudolph JM]]
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[[Category: Nachtschatt S]]
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[[Category: Redecke L]]
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[[Category: Schneider T]]
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[[Category: Schoenherr R]]
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[[Category: Wobbe M]]

Current revision

Trypanosoma brucei IMP dehydrogenase (ori) crystallized in High Five cells reveals native ligands ATP, GDP and phosphate. Diffraction data collection at 100 K in cellulo; CrystFEL processing

PDB ID 8c53

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