8gyw
From Proteopedia
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| - | == | + | ==Cryo-EM structure of human CEPT1 complexed with CDP-choline== |
<StructureSection load='8gyw' size='340' side='right'caption='[[8gyw]], [[Resolution|resolution]] 3.90Å' scene=''> | <StructureSection load='8gyw' size='340' side='right'caption='[[8gyw]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8gyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GYW FirstGlance]. <br> | <table><tr><td colspan='2'>[[8gyw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GYW FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDC:[2-CYTIDYLATE-O-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM'>CDC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDC:[2-CYTIDYLATE-O-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM'>CDC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gyw OCA], [https://pdbe.org/8gyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gyw RCSB], [https://www.ebi.ac.uk/pdbsum/8gyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gyw ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gyw OCA], [https://pdbe.org/8gyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gyw RCSB], [https://www.ebi.ac.uk/pdbsum/8gyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gyw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/CEPT1_HUMAN CEPT1_HUMAN] Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.<ref>PMID:10191259</ref> <ref>PMID:10893425</ref> <ref>PMID:12216837</ref> | + | [https://www.uniprot.org/uniprot/CEPT1_HUMAN CEPT1_HUMAN] Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively (PubMed:10191259, PubMed:10893425, PubMed:12216837, PubMed:37137909). Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface (PubMed:10191259, PubMed:10893425, PubMed:12216837). Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity (PubMed:10191259, PubMed:12216837).<ref>PMID:10191259</ref> <ref>PMID:10893425</ref> <ref>PMID:12216837</ref> <ref>PMID:37137909</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
Cryo-EM structure of human CEPT1 complexed with CDP-choline
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