This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ka4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:45, 7 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ka4.jpg|left|200px]]
 
-
<!--
+
==Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb==
-
The line below this paragraph, containing "STRUCTURE_1ka4", creates the "Structure Box" on the page.
+
<StructureSection load='1ka4' size='340' side='right'caption='[[1ka4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ka4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KA4 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
-
{{STRUCTURE_1ka4| PDB=1ka4 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ka4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ka4 OCA], [https://pdbe.org/1ka4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ka4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ka4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ka4 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CBP1_PYRFU CBP1_PYRFU] Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues, but not Pro, Gly, Asp and Glu.<ref>PMID:10595552</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/1ka4_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ka4 ConSurf].
 +
<div style="clear:both"></div>
-
'''Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb'''
+
==See Also==
-
 
+
*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
-
 
+
== References ==
-
==Overview==
+
<references/>
-
The structure of Pyrococcus furiosus carboxypeptidase (PfuCP) has been determined to 2.2 A resolution using multiwavelength anomalous diffraction (MAD) methods. PfuCP represents the first structure of the new M32 family of carboxypeptidases. The overall structure is comprised of a homodimer. Each subunit is mostly helical with its most pronounced feature being a deep substrate binding groove. The active site lies at the bottom of this groove and contains an HEXXH motif that coordinates the metal ion required for catalysis. Surprisingly, the structure is similar to the recently reported rat neurolysin. Comparison of these structures as well as sequence analyses with other homologous proteins reveal several conserved residues. The roles for these conserved residues in the catalytic mechanism are inferred based on modeling and their location.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1KA4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KA4 OCA].
+
-
 
+
-
==Reference==
+
-
Crystal structure of a novel carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus., Arndt JW, Hao B, Ramakrishnan V, Cheng T, Chan SI, Chan MK, Structure. 2002 Feb;10(2):215-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11839307 11839307]
+
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
-
[[Category: Single protein]]
+
[[Category: Arndt JW]]
-
[[Category: Arndt, J W.]]
+
[[Category: Chan MK]]
-
[[Category: Chan, M K.]]
+
[[Category: Chan SI]]
-
[[Category: Chan, S I.]]
+
[[Category: Cheng T]]
-
[[Category: Cheng, T.]]
+
[[Category: Hao B]]
-
[[Category: Hao, B.]]
+
[[Category: Ramakrishnan V]]
-
[[Category: Ramakrishnan, V.]]
+
-
[[Category: Hexxh motif]]
+
-
[[Category: M32 family]]
+
-
[[Category: Metallopeptidase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:29:35 2008''
+

Current revision

Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb

PDB ID 1ka4

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ka4"
Personal tools