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8gkg

From Proteopedia

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(New page: '''Unreleased structure''' The entry 8gkg is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures)
Current revision (06:22, 6 September 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8gkg is ON HOLD until Paper Publication
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==Human TRPV3 pentamer structure==
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<StructureSection load='8gkg' size='340' side='right'caption='[[8gkg]], [[Resolution|resolution]] 4.38&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8gkg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GKG FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.38&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gkg OCA], [https://pdbe.org/8gkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gkg RCSB], [https://www.ebi.ac.uk/pdbsum/8gkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gkg ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Mutilating palmoplantar keratoderma with periorificial keratotic plaques. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV3_HUMAN TRPV3_HUMAN] Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).<ref>PMID:12077604</ref> <ref>PMID:12077606</ref> <ref>PMID:21593771</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Betancourt JM]]
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[[Category: Lansky S]]
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[[Category: Scheuring S]]

Current revision

Human TRPV3 pentamer structure

PDB ID 8gkg

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