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1jfn

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(New page: 200px<br /> <applet load="1jfn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jfn" /> '''SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(...)
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[[Image:1jfn.gif|left|200px]]<br />
 
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<applet load="1jfn" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jfn" />
 
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'''SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A) KRINGLE IV TYPE 6'''<br />
 
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==Overview==
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==SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A) KRINGLE IV TYPE 6==
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The structure of apo(a) KIVT6 was investigated by two- and, three-dimensional homo- and heteronuclear NMR spectroscopy. The solution, structure of apo(a) KIVT6 contains only a small amount of regular, secondary structure elements, comprising a short piece of antiparallel, beta-sheet formed by residues Trp62-Tyr64 and Trp72-Tyr74, a short piece, of parallel beta-sheet formed by the residues Cys1-Tyr2 and Thr78-Gln79, and a small 3(10)-helix within residues Thr38-Tyr40. The backbone as well, as the side chains are arranged in a way similar to those of apo(a) KIVT7, apo(a) KIVT10, and plasminogen K4. We determined additionally the K(d), value of 0.31 +/- 0.04 mM for the binding of epsilon-aminocaproic acid, (EACA) to apo(a) KIVT6 and mapped the binding region on apo(a) KIVT6 by, means of chemical shift perturbation. This lysine binding activity, which, was reported to occur within apo(a) KIVT5-8, is functionally different, from the lysine binding activity found for apo(a) KIVT10.
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<StructureSection load='1jfn' size='340' side='right'caption='[[1jfn]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1jfn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JFN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JFN FirstGlance]. <br>
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Known diseases associated with this structure: Coronary artery disease, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=152200 152200]], LPA deficiency, congenital OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=152200 152200]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jfn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfn OCA], [https://pdbe.org/1jfn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jfn RCSB], [https://www.ebi.ac.uk/pdbsum/1jfn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jfn ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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1JFN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JFN OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref>
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==Reference==
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== Evolutionary Conservation ==
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Solution structure of human apolipoprotein(a) kringle IV type 6., Maderegger B, Bermel W, Hrzenjak A, Kostner GM, Sterk H, Biochemistry. 2002 Jan 15;41(2):660-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11781107 11781107]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jf/1jfn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jfn ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bermel, W.]]
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[[Category: Bermel W]]
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[[Category: Hrzenjak, A.]]
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[[Category: Hrzenjak A]]
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[[Category: Kostner, G.M.]]
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[[Category: Kostner GM]]
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[[Category: Maderegger, B.]]
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[[Category: Maderegger B]]
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[[Category: Sterk, H.]]
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[[Category: Sterk H]]
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[[Category: kringle domain]]
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[[Category: lp(a)]]
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[[Category: protein-protein recognition]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:40:27 2007''
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Current revision

SOLUTION STRUCTURE OF HUMAN APOLIPOPROTEIN(A) KRINGLE IV TYPE 6

PDB ID 1jfn

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