4v7r
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4v7r]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o2z 3o2z], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o30 3o30], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o58 3o58] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o5h 3o5h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V7R FirstGlance]. <br> | <table><tr><td colspan='2'>[[4v7r]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o2z 3o2z], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o30 3o30], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o58 3o58] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3o5h 3o5h]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V7R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V7R FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v7r OCA], [https://pdbe.org/4v7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v7r RCSB], [https://www.ebi.ac.uk/pdbsum/4v7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v7r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v7r OCA], [https://pdbe.org/4v7r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v7r RCSB], [https://www.ebi.ac.uk/pdbsum/4v7r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v7r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> | [https://www.uniprot.org/uniprot/RSSA1_YEAST RSSA1_YEAST] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.<ref>PMID:9973221</ref> <ref>PMID:14627813</ref> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Crystal structures of prokaryotic ribosomes have described in detail the universally conserved core of the translation mechanism. However, many facets of the translation process in eukaryotes are not shared with prokaryotes. The crystal structure of the yeast 80S ribosome determined at 4.15 angstrom resolution reveals the higher complexity of eukaryotic ribosomes, which are 40% larger than their bacterial counterparts. Our model shows how eukaryote-specific elements considerably expand the network of interactions within the ribosome and provides insights into eukaryote-specific features of protein synthesis. Our crystals capture the ribosome in the ratcheted state, which is essential for translocation of mRNA and transfer RNA (tRNA), and in which the small ribosomal subunit has rotated with respect to the large subunit. We describe the conformational changes in both ribosomal subunits that are involved in ratcheting and their implications in coordination between the two associated subunits and in mRNA and tRNA translocation. | ||
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| - | Crystal structure of the eukaryotic ribosome.,Ben-Shem A, Jenner L, Yusupova G, Yusupov M Science. 2010 Nov 26;330(6008):1203-9. PMID:21109664<ref>PMID:21109664</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 4v7r" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
Current revision
Yeast 80S ribosome.
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