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Sigma factor 3D structures

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Current revision (15:39, 16 December 2023) (edit) (undo)
 
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Line 19: Line 19:
**[[1h3l]] – ScSF N terminal – ''Streptomyces coelicolor''<br />
**[[1h3l]] – ScSF N terminal – ''Streptomyces coelicolor''<br />
**[[5fgm]] – ScSF-R region 4<br />
**[[5fgm]] – ScSF-R region 4<br />
 +
**[[7qh5]] – SF-G1 – ''Streptomyces tsukubensis''<br />
**[[5mww]] – BsSF-A region 1.1 - ''Bacillus subtilis'' - NMR <br />
**[[5mww]] – BsSF-A region 1.1 - ''Bacillus subtilis'' - NMR <br />
 +
**[[8b3z]] – BsSF-E N terminal <br />
**[[5xe7]] – MtSF-J – ''Mycobacterium tuberculosis''<br />
**[[5xe7]] – MtSF-J – ''Mycobacterium tuberculosis''<br />
Line 37: Line 39:
**[[1tlh]] – EcSF-70 region 4 + anti-σ factor<br />
**[[1tlh]] – EcSF-70 region 4 + anti-σ factor<br />
**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM <br />
**[[1rp3]], [[1sc5]] – AaSF-28 + anti-σ factor FLGM <br />
-
**[[6ivu]] – SF-1 + anti-σ factor – ''Clostridium thermocellum''<br />
+
**[[6ivu]] – CtSF-1 + anti-σ factor – ''Clostridium thermocellum''<br />
**[[5wur]] – BsSF-W + anti-σ factor <br />
**[[5wur]] – BsSF-W + anti-σ factor <br />
**[[5uxx]] – SF + anti-σ factor – ''Bartonella quintana''<br />
**[[5uxx]] – SF + anti-σ factor – ''Bartonella quintana''<br />
Line 51: Line 53:
**[[4yg2]], [[5uag]], [[5uaj]], [[5uaq]] – EcSF-70 + RNAP subunits α,β,β’,ω <br />
**[[4yg2]], [[5uag]], [[5uaj]], [[5uaq]] – EcSF-70 + RNAP subunits α,β,β’,ω <br />
**[[5ui8]] – EcSF-45 + RNAP subunits α,β,β’,ω <br />
**[[5ui8]] – EcSF-45 + RNAP subunits α,β,β’,ω <br />
-
**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]], [[5uac]], [[5uah]], [[5ual]], [[4zh3]], [[4zh4]] – EcSF-70 + RNAP subunits α,β,β’,ω + antibiotic <br />
 
-
**[[4xsx]], [[4xsy]], [[4xsz]] – EcSF-70 + RNAP subunits α,β,β’,ω + antibiotic <br />
 
**[[6byu]] – EcSF-70 + RNAP subunits α,β,β’,ω + ppApp <br />
**[[6byu]] – EcSF-70 + RNAP subunits α,β,β’,ω + ppApp <br />
**[[4mey]], [[4ljz]], [[4lk1]], [[6cux]] – EcSF-70 + RNAP subunits α,β,β’,ω <br />
**[[4mey]], [[4ljz]], [[4lk1]], [[6cux]] – EcSF-70 + RNAP subunits α,β,β’,ω <br />
Line 65: Line 65:
**[[6onu]], [[6ono]] – MtSF-A region 4 + WHIB1<br />
**[[6onu]], [[6ono]] – MtSF-A region 4 + WHIB1<br />
**[[5zx3]] – MtSF-H + RNAP subunits α,β,β’,ω <br />
**[[5zx3]] – MtSF-H + RNAP subunits α,β,β’,ω <br />
-
**[[6fbv]] – MtSF-A + RNAP subunits α,β,β’,ω - SP Cryo EM<br />
+
**[[6fbv]] – MtSF-A + RNAP subunits α,β,β’,ω - Cryo EM<br />
 +
**[[7pp4]], [[7q4u]], [[7q59]], [[7zf2]] – MtSF-B + RNAP subunits α,β,β’,ω - Cryo EM<br />
**[[6c05]], [[6c06]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA - Cryo EM<br />
**[[6c05]], [[6c06]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA - Cryo EM<br />
**[[3wod]], [[2a6e]], [[2cw0]], [[5tmf]] – TtSF-A + RNAP subunits α,β,β’,ω - ''Thermus thermophilus'' <br />
**[[3wod]], [[2a6e]], [[2cw0]], [[5tmf]] – TtSF-A + RNAP subunits α,β,β’,ω - ''Thermus thermophilus'' <br />
-
**[[4mq9]], [[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]] – TtSF-70 + RNAP subunits α,β,β’,ω + antibiotic <br />
 
**[[2be5]] – TtSF-70 + RNAP subunits α,β,β’,ω + inhibitor<br />
**[[2be5]] – TtSF-70 + RNAP subunits α,β,β’,ω + inhibitor<br />
**[[6pfj]], [[6pfv]] – ScSF (mutant) + AMFC protein<br />
**[[6pfj]], [[6pfv]] – ScSF (mutant) + AMFC protein<br />
Line 77: Line 77:
**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''<br />
**[[4cxf]] – SF CNRH + CNRY – ''Cupriavidus metallidurans''<br />
**[[4g6d]], [[4g8x]], [[4g94]] – SF-70 region 4 + Orf067 – ''Staphylococcus aureus''<br />
**[[4g6d]], [[4g8x]], [[4g94]] – SF-70 region 4 + Orf067 – ''Staphylococcus aureus''<br />
-
**[[5yix]] – SF-70 + GCRA - ''Caulobacter crescentus''<br />
+
**[[5yix]] – CcSF-70 + GcrA - ''Caulobacter crescentus''<br />
-
**[[6in7]] – SF-H + ALGU – Pseudomonas aeruginosa<br />
+
**[[6in7]] – PaSF-H + ALGU – ''Pseudomonas aeruginosa''<br />
**[[6eyd]] – MsSF-A + RNAP subunits α,β,β’,ω - ''Mycobacterium smegmatis'' – Cryo EM <br />
**[[6eyd]] – MsSF-A + RNAP subunits α,β,β’,ω - ''Mycobacterium smegmatis'' – Cryo EM <br />
-
**[[6dxo]] – SF-A + BLDN – ''Streptomyces venezuelae''<br />
+
**[[6dxo]] – SvSF-A + BLDN – ''Streptomyces venezuelae''<br />
 +
**[[7vf9]] – PaSF-38 + RNAP subunits α,β,β’,ω - Cryo EM<br />
-
*E. coli sigma factor complex with protein, DNA and RNA
+
*E. coli sigma factor-70 complex with protein, DNA and RNA
**[[6p1k]], [[7khb]] – EcSF-70 + EcRNAP subunits α,β,β’,ω - Cryo EM<br />
**[[6p1k]], [[7khb]] – EcSF-70 + EcRNAP subunits α,β,β’,ω - Cryo EM<br />
Line 91: Line 92:
**[[7khc]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + POP – Cryo EM<br />
**[[7khc]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + POP – Cryo EM<br />
**[[4yln]], [[4ylo]], [[4ylp]], [[6n62]], [[6utv]], [[6utw]], [[6utx]] [[6uty]], [[6utz]], [[6uu0]], [[6uu1]], [[6uuc]] [[6uu3]], [[6uu4]], [[6uu5]], [[6uu6]], [[6uu7]], [[6uu8]], [[6uu2]], [[6uua]], [[6uuc]] – EcSF-70 in transcription initiation complex<br />
**[[4yln]], [[4ylo]], [[4ylp]], [[6n62]], [[6utv]], [[6utw]], [[6utx]] [[6uty]], [[6utz]], [[6uu0]], [[6uu1]], [[6uuc]] [[6uu3]], [[6uu4]], [[6uu5]], [[6uu6]], [[6uu7]], [[6uu8]], [[6uu2]], [[6uua]], [[6uuc]] – EcSF-70 in transcription initiation complex<br />
-
**[[6b6h]], [[6xl5]], [[6xl9]], [[6xlj]], [[6xll]] – EcSF-70 in transcription activation complex - Cryo EM<br />
+
**[[6b6h]], [[6xl5]], [[6xl9]], [[6xlj]], [[6xll]], [[7vwy]], [[8igr]], [[8igs]] – EcSF-70 in transcription activation complex - Cryo EM<br />
**[[5nss]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + phage shock protein F + DNA - Cryo EM<br />
**[[5nss]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + phage shock protein F + DNA - Cryo EM<br />
-
**[[5nsr]], [[6gh6]], [[6gh5]], [[6gfw]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
+
**[[5nsr]], [[6gh6]], [[6gh5]], [[6gfw]], [[7szk]] – EcSF-54 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
**[[7bef]], [[7beg]], [[7chw]], [[7mkd]], [[7mke]], [[7mki]], [[7mkj]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
**[[7bef]], [[7beg]], [[7chw]], [[7mkd]], [[7mke]], [[7mki]], [[7mkj]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
**[[6n61]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + capistruin + DNA<br />
**[[6n61]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + capistruin + DNA<br />
**[[6n60]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + microcin + DNA<br />
**[[6n60]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + microcin + DNA<br />
**[[6p18]] – EcSF-70 in transcription antitermination complex + protein Q<br />
**[[6p18]] – EcSF-70 in transcription antitermination complex + protein Q<br />
-
**[[6jnx]] – EcSF-70 in transcription antitermination complex + protein Q – Cryo EM<br />
+
**[[6jnx]], [[7ubm]] – EcSF-70 in transcription antitermination complex + protein Q – Cryo EM<br />
 +
**[[7ubn]] – EcSF-70 in transcription antitermination complex + NusA – Cryo EM<br />
**[[6jbq]] – EcSF-E in transcription initiation complex – Cryo EM<br />
**[[6jbq]] – EcSF-E in transcription initiation complex – Cryo EM<br />
**[[5vt0]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + RNA – Cryo EM<br />
**[[5vt0]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + RNA – Cryo EM<br />
**[[6k4y]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + anti-SF + MOTA + DNA – Cryo EM<br />
**[[6k4y]] – EcSF-70 + EcRNAP subunits α,β,β’,ω + anti-SF + MOTA + DNA – Cryo EM<br />
-
**[[6ldi]], [[6xh7]], [[6xh8]], [[7c17]] – EcSF-70 in transcription activation complex + Cuer – Cryo EM<br />
+
**[[6ldi]], [[6xh7]], [[6xh8]], [[7c17]] – EcSF-70 in transcription activation complex + CueR – Cryo EM<br />
**[[6pb4]], [[6pb5]], [[6pb6]] – EcSF-70 in transcription activation complex + Crp – Cryo EM<br />
**[[6pb4]], [[6pb5]], [[6pb6]] – EcSF-70 in transcription activation complex + Crp – Cryo EM<br />
 +
**[[7vwz]] – EcSF-70 in transcription activation complex + right origin-binding protein – Cryo EM<br />
 +
**[[7w5w]], [[7w5x]], [[7w5y]] – EcSF-70 in transcription activation complex + SoxS – Cryo EM<br />
 +
**[[8jo2]] – EcSF-70 in transcription activation complex + BasR – Cryo EM<br />
**[[6n57]], [[6n58]] – EcSF-70 in transcription initiation complex + Tsar – Cryo EM<br />
**[[6n57]], [[6n58]] – EcSF-70 in transcription initiation complex + Tsar – Cryo EM<br />
**[[6psq]], [[6psr]], [[6pss]], [[6pst]], [[6psu]], [[6psv]], [[6psw]] – EcSF-70 in transcription initiation complex + Trar – Cryo EM<br />
**[[6psq]], [[6psr]], [[6pss]], [[6pst]], [[6psu]], [[6psv]], [[6psw]] – EcSF-70 in transcription initiation complex + Trar – Cryo EM<br />
Line 112: Line 117:
**[[7khi]] – EcSF-70 in transcription open promoter complex + DKSA + G4P – Cryo EM<br />
**[[7khi]] – EcSF-70 in transcription open promoter complex + DKSA + G4P – Cryo EM<br />
**[[7khc]] – EcSF-70 in transcription closed promoter complex – Cryo EM<br />
**[[7khc]] – EcSF-70 in transcription closed promoter complex – Cryo EM<br />
-
**[[6xlm]] – EcSF-70 in elongation complex – Cryo EM<br />
+
**[[6xlm]], [[7n4e]], [[7xui]] – EcSF-70 in elongation complex – Cryo EM<br />
-
**[[6pmi]], [[6pmj]] – EcSF-28 in transcription initiation complex – Cryo EM<br />
+
-
**[[5ipl]], [[5ipm]], [[5ipn]] – EcSF-38 in transcription initiation complex <br />
+
*Other sigma factor complex with protein, DNA and RNA
*Other sigma factor complex with protein, DNA and RNA
Line 121: Line 124:
**[[7rdq]] – TtSF-A in reiterative transcription complex – Cryo EM<br />
**[[7rdq]] – TtSF-A in reiterative transcription complex – Cryo EM<br />
**[[5vo8]] – TtSF-A in reiterative transcription complex + GTP<br />
**[[5vo8]] – TtSF-A in reiterative transcription complex + GTP<br />
-
**[[6kqd]], [[6kqe]], [[6kqf]], [[6kqg]], [[6kqh]], [[6kql]], [[6kqm]], [[6kqn]], [[6l74]], [[6lts]], [[5e17]], [[5e18]] – TtSF-A in initial transcription complex <br />
+
**[[6kqd]], [[6kqe]], [[6kqf]], [[6kqg]], [[6kqh]], [[6kql]], [[6kqm]], [[6kqn]], [[6l74]], [[6lts]], [[5e17]], [[5e18]] – TtSF-A in initial
 +
transcription complex <br />
**[[6wox]], [[6woy]] – TtSF-A in initial transcription complex + CPT<br />
**[[6wox]], [[6woy]] – TtSF-A in initial transcription complex + CPT<br />
**[[1smy]] – TtSF + RNAP subunits α,β,β’,ω + G4P<br />
**[[1smy]] – TtSF + RNAP subunits α,β,β’,ω + G4P<br />
Line 138: Line 142:
**[[4xlr]], [[4xls]] – TaSF-A in transcription initiation complex + CarD-like transcriptional regulator<br />
**[[4xlr]], [[4xls]] – TaSF-A in transcription initiation complex + CarD-like transcriptional regulator<br />
**[[1rio]] - TaSF-A region 4 + repression protein CI + DNA<br />
**[[1rio]] - TaSF-A region 4 + repression protein CI + DNA<br />
-
**[[6dcf]] – MtSF-A in transcription initiation complex + RBPA<br />
+
**[[5uha]], [[5uh5]], [[5uh8]], [[5uh9]], [[7u22]] – MtSF-A in transcription initiation complex<br />
-
**[[5uha]], [[5uh5]], [[5uh8]], [[5uh9]], [[7rwi]] – MtSF-A in transcription initiation complex<br />
+
**[[6dcf]] – MtSF-A in transcription initiation complex + RbpA<br />
**[[6dcf]] – MtSF-A in transcription initiation complex + RbpA<br />
 +
**[[8hih]] – MtSF-A in transcription initiation complex + transctriptional regulatory protein – Cryo EM<br />
**[[6c04]], [[7kin]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA - Cryo EM<br />
**[[6c04]], [[7kin]] – MtSF-A + RNAP subunits α,β,β’,ω + RbpA + DNA - Cryo EM<br />
**[[7kif]], [[7kim]] – MtSF-A + RNAP subunits α,β,β’,ω + WhiB7 + DNA - Cryo EM<br />
**[[7kif]], [[7kim]] – MtSF-A + RNAP subunits α,β,β’,ω + WhiB7 + DNA - Cryo EM<br />
Line 146: Line 150:
**[[6jcy]], [[6jcx]], [[5zx2]] – MtSF-H in transcription initiation complex<br />
**[[6jcy]], [[6jcx]], [[5zx2]] – MtSF-H in transcription initiation complex<br />
**[[6kon]], [[6koo]], [[6kop]], [[6koq]] – MtSF-H in transcription initiation complex <br />
**[[6kon]], [[6koo]], [[6kop]], [[6koq]] – MtSF-H in transcription initiation complex <br />
-
**[[6dve]], [[6dvd]] – MtSF-L in transcription initiation complex<br />
+
**[[6dve]], [[6dvd]], [[7rwi]] – MtSF-L in transcription initiation complex<br />
**[[6dvc]], [[6dvb]], [[6dv9]], [[6tye]], [[6tyf]], [[6tyg]] – MtSF-L in transcription initiation complex <br />
**[[6dvc]], [[6dvb]], [[6dv9]], [[6tye]], [[6tyf]], [[6tyg]] – MtSF-L in transcription initiation complex <br />
**[[5tw1]], [[6cce]] – MsSF-A in transcription initiation complex + peptide - ''Mycobacterium smegmatis''<br />
**[[5tw1]], [[6cce]] – MsSF-A in transcription initiation complex + peptide - ''Mycobacterium smegmatis''<br />
**[[5vi5]], [[5vi8]], [[6vvv]] – MsSF-A in transcription initiation complex<br />
**[[5vi5]], [[5vi8]], [[6vvv]] – MsSF-A in transcription initiation complex<br />
**[[7p5x]] – MsSF-A in transcription initiation complex + PafBC – Cryo EM<br />
**[[7p5x]] – MsSF-A in transcription initiation complex + PafBC – Cryo EM<br />
-
**[[7l7b]] – SF-A + RNAP subunits α,β,β’,ω + antibiotic – Clostridia bacterium - Cryo EM<br />
+
**[[8i24]] – AtSF-I6 + RNAP subunits α,β,β’,ω + DNA – ''Acetivibrio thermocellum'' - Cryo EM<br />
 +
**[[8i23]] – AtSF-I1 + RNAP subunits α,β,β’,ω + DNA - Cryo EM<br />
 +
**[[7ye1]] , [[7ye2]] – CcSF-70 + RNAP subunits α,β,β’,ω + DNA + GcrA – Cryo EM<br />
 +
**[[7f0r]] – PaSF-38 in transcription activation complex + SutA – Cryo EM<br />
 +
**[[7xl3]], [[7xl4]] – PaSF-S in transcription activation complex + SutA – Cryo EM<br />
 +
**[[7xya]] – PaSF-70 in transcription antitermination complex + ALPA – Cryo EM<br />
 +
**[[8gzg]], [[8gzh]] – SF-A + RNAP subunits α,β,β’,ω + DNA + RNA – ''Synechocystis'' - Cryo EM<br />
 +
**[[8h40]] – AnSF-A + RNAP subunits α,β,β’,ω + DNA + NtcA – ''Anabaena'' - Cryo EM<br />
 +
**[[8h3v]] – AnSF-A + RNAP subunits α,β,β’,ω + DNA + NtcA + NtcB - Cryo EM<br />
 +
**[[7vpd]], [[7vpz]], [[7x74]], [[7x75]], [[7x76]] – ScSF-A + RNAP subunits α,β,β’,ω + metal uptake regulation protein + DNA + RNA - Cryo EM<br />
 +
**[[68hkc]] – EcSF-32 in transcription initiation complex – Cryo EM<br />
 +
**[[6pmi]], [[6pmj]] – EcSF-28 in transcription initiation complex – Cryo EM<br />
 +
**[[5ipl]], [[5ipm]], [[5ipn]] – EcSF-38 in transcription initiation complex <br />
 +
**[[8dy7]], [[8dy9]] – SvSF-A + RNAP subunits α,β,β’,ω + WhiA + WhiB + RbpA + DNA - Cryo EM<br />
 +
 
*Sigma factor complex with protein and DNA and antibiotics
*Sigma factor complex with protein and DNA and antibiotics
Line 157: Line 175:
**[[4oin]], [[4oip]], [[4oiq]], [[4oir]], [[5x21]] – TtSF-A in transcription initiation complex + antibiotic <br />
**[[4oin]], [[4oip]], [[4oiq]], [[4oir]], [[5x21]] – TtSF-A in transcription initiation complex + antibiotic <br />
**[[6cuu]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
**[[6cuu]] – TtSF-A + TtRNAP subunits α,β,β’,ω + DNA + antibiotic<br />
 +
**[[2a68]], [[2a69]], [[2a6h]], [[3dxj]], [[3eql]], [[4mq9]] – TtSF-70 + RNAP subunits α,β,β’,ω + antibiotic <br />
**[[5uhg]] – MtSF-A in transcription initiation complex + antibiotic + inhibitor<br />
**[[5uhg]] – MtSF-A in transcription initiation complex + antibiotic + inhibitor<br />
**[[5uh6]], [[5uhc]], [[5uhd]], [[5uhb]] – MtSF-A in transcription initiation complex + antibiotic<br />
**[[5uh6]], [[5uhc]], [[5uhd]], [[5uhb]] – MtSF-A in transcription initiation complex + antibiotic<br />
**[[6bzo]] – MtSF-A in transcription initiation complex + RbpA + antibiotic - Cryo EM<br />
**[[6bzo]] – MtSF-A in transcription initiation complex + RbpA + antibiotic - Cryo EM<br />
-
**[[6ccv]] – MsSF-A in transcription initiation complex + peptide + RbpA + antibiotic<br />
 
**[[6vvt]], [[6vvx]], [[6vvz]] – MtSF-A in transcription initiation complex + antibiotic – Cryo EM<br />
**[[6vvt]], [[6vvx]], [[6vvz]] – MtSF-A in transcription initiation complex + antibiotic – Cryo EM<br />
**[[6vvy]], [[6vw0]] – MtSF-A in transcription open promoter complex + antibiotic – Cryo EM<br />
**[[6vvy]], [[6vw0]] – MtSF-A in transcription open promoter complex + antibiotic – Cryo EM<br />
**[[6m7j]] – MtSF-A + RNAP subunits α,β,β’,ω + RBPA + DNA + antibiotic – Cryo EM<br />
**[[6m7j]] – MtSF-A + RNAP subunits α,β,β’,ω + RBPA + DNA + antibiotic – Cryo EM<br />
**[[6eec]], [[6ee8]], [[6edt]] – MtSF-A + RNAP subunits α,β,β’,ω + RBPA + CARD + DNA + antibiotic – Cryo EM<br />
**[[6eec]], [[6ee8]], [[6edt]] – MtSF-A + RNAP subunits α,β,β’,ω + RBPA + CARD + DNA + antibiotic – Cryo EM<br />
 +
**[[6ccv]] – MsSF-A in transcription initiation complex + peptide + RbpA + antibiotic<br />
 +
**[[7l7b]] – SF-A + RNAP subunits α,β,β’,ω + antibiotic – Clostridia bacterium - Cryo EM<br />
 +
**[[4mex]], [[4kmu]], [[4kn4]], [[4kn7]], [[4xsx]], [[4xsy]], [[4xsz]] [[4zh3]], [[4zh4]], [[5uac]], [[5uah]], [[5ual]] – EcSF-70 + RNAP subunits α,β,β’,ω + antibiotic <br />
 +
**[[7szj]] – EcSF-70 + RNAP subunits α,β,β’,ω + antibiotic – Cryo EM<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of sigma factor

Updated on 16-December-2023 

transcription complex


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Jaime Prilusky

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